Rabbit anti-Human TMC6 Polyclonal Antibody | anti-TMC6 antibody

TMC6, NT (TMC6, EVER1, EVIN1, Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1, Protein LAK-4) (APC)

Cat. Num. AAA6356153

• Gene Names: TMC6; EV1; EVER1; EVIN1; LAK-4P
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TMC6; Polyclonal Antibody; NT (TMC6; EVER1; EVIN1; Transmembrane channel-like protein 6; Epidermodysplasia verruciformis protein 1; Protein LAK-4) (APC); Protein LAK-4; anti-TMC6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-TMC6 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TMC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-188 amino acids from the N-terminal region of human TMC6.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(TMC6 Antibody (N-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the TMC6 antibody detected the TMC6 protein (arrow).)

Related Product Information for anti-TMC6 antibody

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs.

Product Categories/Family for anti-TMC6 antibody

Antibodies; Transmembrane Proteins

References

McDermott, D.F., et al. Pediatr Dermatol 26(3):306-310(2009). Lazarczyk, M., et al. J. Exp. Med. 205(1):35-42(2008). Zuo, Y.G., et al. J. Dermatol. Sci. 44(3):153-159(2006). Olsen, J.V., et al. Cell 127(3):635-648(2006). Donfack, J., et al. Int. J. Pediatr. Otorhinolaryngol. 70(7):1235-1240(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 187608784
• NCBI GeneID: 11322
• NCBI Accession #: NP_009198.4; NP_001120670.1
• NCBI GenBank Nucleotide #: NM_007267.6
• UniProt Accession #: Q7Z403; O43284; Q45VJ2; Q8IU98; Q8IUI7; Q8IWU8; Q8TEQ7; Q9HAG5
• Molecular Weight: 32,485 Da
• NCBI Official Full Name: transmembrane channel-like protein 6
• NCBI Official Synonym Full Names: transmembrane channel-like 6
• NCBI Official Symbol: TMC6
• NCBI Official Synonym Symbols: EV1; EVER1; EVIN1; LAK-4P
• NCBI Protein Information: transmembrane channel-like protein 6; protein LAK-4; epidermodysplasia verruciformis 1; expressed in activated T/LAK lymphocytes; epidermodysplasia verruciformis protein 1
• UniProt Protein Name: Transmembrane channel-like protein 6
• Protein Family: Transmembrane channel-like protein
• UniProt Gene Name: TMC6
• UniProt Synonym Gene Names: EVER1; EVIN1
• UniProt Entry Name: TMC6_HUMAN

NCBI Description

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]

Uniprot Description

TMC6: Defects in TMC6 are a cause of epidermodysplasia verruciformis (EV). It is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. Belongs to the TMC family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; nuclear membrane; endoplasmic reticulum; cytoplasm; integral to membrane

Molecular Function: protein binding

Biological Process: ion transport

Disease: Epidermodysplasia Verruciformis