Immunohistochemistry (IHC)
(Human Testis (formalin-fixed, paraffin-embedded) stained with TMC6 antibody at 5ug/ml followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
Rabbit anti-Human TMC6 Polyclonal Antibody | anti-TMC6 antibody
TMC6, NT (Transmembrane Channel-Like Protein 6, Epidermodysplasia Verruciformis Protein 1, Protein LAK-4, EVER1, EVIN1)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: Western Blot: 1-2ug/ml
Immunohistochemistry (Formalin-fixed, paraffin-embedded): 5ug/ml
Immunohistochemistry (IHC)
(Human Testis (formalin-fixed, paraffin-embedded) stained with TMC6 antibody at 5ug/ml followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
Immunohistochemistry (IHC)
(Human Testis (formalin-fixed, paraffin-embedded) stained with TMC6 antibody at 5ug/ml followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
Western Blot (WB)
(Western blot analysis of EVER1 in A-20 cell lysate with EVER1 antibody at (A) 1 and (B) 2ug/ml.)
Western Blot (WB)
(Western blot analysis of EVER1 in A-20 cell lysate with EVER1 antibody at (A) 1 and (B) 2ug/ml.)
NCBI and Uniprot Product Information
NCBI Description
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Probable ion channel
By similarity.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.1.
Tissue specificity: Expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes. Ref.2 Ref.3
Involvement in disease: Epidermodysplasia verruciformis (EV) [MIM:226400]: Rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions.Note: The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarities: Belongs to the TMC family.
Sequence caution: The sequence AAH35648.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA24179.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB84891.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on TMC6
Similar Products
Product Notes
The TMC6 tmc6 (Catalog #AAA646809) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TMC6, NT (Transmembrane Channel-Like Protein 6, Epidermodysplasia Verruciformis Protein 1, Protein LAK-4, EVER1, EVIN1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TMC6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in ELISA, Western Blot and Immunohistochemistry. Dilution: Western Blot: 1-2ug/ml Immunohistochemistry (Formalin-fixed, paraffin-embedded): 5ug/ml. Researchers should empirically determine the suitability of the TMC6 tmc6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TMC6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
