Immunohistochemistry (IHC)
(Immunochemical staining of human TM9SF2 in human prostate with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human TM9SF2 Polyclonal Antibody | anti-TM9SF2 antibody
Anti-TM9SF2 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
TM9SF2; Polyclonal Antibody; Anti-TM9SF2 Antibody; Rabbit Polyclonal; TM9SF2 Antibody; Rabbit PAb; Antigen Affinity Purified; transmembrane 9 superfamily member 2; anti-TM9SF2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human TM9SF2
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-TM9SF2 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human TM9SF2 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human TM9SF2 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human TM9SF2 in human prostate with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human TM9SF2 in human prostate with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human TM9SF2 in human pancreas with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human TM9SF2 in human pancreas with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-TM9SF2 antibody
The transmembrane 9 (TM9) proteins (also known as nonaspanins) are a group of highly conserved proteins with 9 transmembrane domains. They include 3 members in the amoeba Dictyostelium discoideum (Phg1A, B, C), in the yeast Saccharomyces cerevisiae (TMN1-3) and in Drosophila melanogaster flies (TM9SF2, TM9SF3, TM9SF4) and 4 members in humans (TM9 superfamily proteins TM9SF1 to TM9SF4). They are found in the endosomal compartments of yeast, Dictyostelium and human cells where they possibly contribute to cell migration, vesicular transport, endocytic trafficking and autophagy. In Dictyostelium, TM9SF4/Phg1A is required for the phagocytosis and killing of bacteria. Moreover, the two Dictyostelium TM9 proteins Phg1A and Phg1B synergistically contribute to the expression and/or localization of transmembrane proteins. The function of TM9SF4 in phagocytosis is conserved in human immune cells, where TM9SF4 overexpression contributes to enhanced phagocytic activity of metastatic tumour cells, and in Drosophila. In Drosophila, TM9SF4 mutant macrophages and TM9SF4-silenced S2 cells are notably defective in phagocytosis of Escherichia coli-derived particles. The closely related protein TM9SF2 acts redundantly with TM9SF4 in the phagocytosis of various types of particles and in the control of the actin cytoskeleton. TM9SF2 is a colorectal cancer (CRC) oncogene.
References
Perrin J, et al. (2015) The nonaspanins tm9sf2 and tm9sf4 regulate the plasma membrane localization and signalling activity of the peptidoglycan recognition protein pgrp-lc in drosophila. J Innate Immun 7 (1): 37-46.Li Q, et al. (2019) Linc01232 exerts oncogenic activities in pancreatic adenocarcinoma via regulation of tm9sf2. Cell Death Dis 10 (10): 698.Clark CR, et al. (2018) Transposon mutagenesis screen in mice identifies tm9sf2 as a novel colorectal cancer oncogene. Sci Rep 8 (1): 15327.
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Product Notes
The TM9SF2 (Catalog #AAA8109125) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TM9SF2 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TM9SF2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the TM9SF2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TM9SF2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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