Western Blot (WB)
(TM165 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TM165 antibody detected the TM165 protein (arrow).)
Rabbit anti-Human TM165 Polyclonal Antibody | anti-TMEM165 antibody
TM165 Antibody (N-term)
Western Blot (WB)
(TM165 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TM165 antibody detected the TM165 protein (arrow).)
Western Blot (WB)
(TM165 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TM165 antibody detected the TM165 protein (arrow).)
Flow Cytometry (FC/FACS)
(TM165 Antibody (N-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(TM165 Antibody (N-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Hu, R.M., et al. Proc. Natl. Acad. Sci. U.S.A. 97(17):9543-9548(2000)
Akagi, J., et al. Biochem. Biophys. Res. Commun. 157(2):548-557(1988)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a predicted transmembrane protein with a perinuclear Golgi-like distribution in fibroblasts. Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation, type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Uniprot Description
TMEM165: Defects in TMEM165 are the cause of congenital disorder of glycosylation type 2K (CDG2K). An autosomal recessive disorder with a variable phenotype. Affected individuals show psychomotor retardation and growth retardation, and most have short stature. Other features include dysmorphism, hypotonia, eye abnormalities, acquired microcephaly, hepatomegaly, and skeletal dysplasia. Congenital disorders of glycosylation are caused by a defect in glycoprotein biosynthesis and characterized by under- glycosylated serum glycoproteins and a wide variety of clinical features. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the GDT1 family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: Golgi membrane; Golgi apparatus; intracellular membrane-bound organelle; lysosomal membrane; early endosome membrane; late endosome membrane; integral to membrane; trans-Golgi network membrane; endosome membrane
Biological Process: cellular calcium ion homeostasis; protein amino acid N-linked glycosylation; Golgi calcium ion transport
Disease: Congenital Disorder Of Glycosylation, Type Iik
Research Articles on TMEM165
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Product Notes
The TMEM165 tmem165 (Catalog #AAA9207789) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 17-45. The TM165 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TM165 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the TMEM165 tmem165 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TM165, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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