Rabbit TLX1 Polyclonal Antibody | anti-TLX1 antibody

TLX1 Polyclonal Antibody

Cat. Num. AAA3010388

• Gene Names: TLX1; TCL3; HOX11
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TLX1; Polyclonal Antibody; TLX1 Polyclonal Antibody; HOX11; TCL3; anti-TLX1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TLX1 polyclonal antibody detects endogenous levels of TLX1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 330

• Applicable Applications for anti-TLX1 antibody: Western Blot (WB)
• Application Notes: WB: 1:1000-1:2000
• Immunogen: Recombinant protein of human TLX1
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using TLX1 antibody.)

Related Product Information for anti-TLX1 antibody

This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 5031757
• NCBI GeneID: 3195
• NCBI Accession #: NP_005512
• NCBI GenBank Nucleotide #: NP_005512.1
• UniProt Accession #: P31314
• Molecular Weight: ~ 40kDa
• NCBI Official Full Name: T-cell leukemia homeobox protein 1 isoform 1
• NCBI Official Synonym Full Names: T cell leukemia homeobox 1
• NCBI Official Symbol: TLX1
• NCBI Official Synonym Symbols: TCL3; HOX11
• NCBI Protein Information: T-cell leukemia homeobox protein 1
• UniProt Protein Name: T-cell leukemia homeobox protein 1
• Protein Family: T-cell leukemia homeobox protein
• UniProt Gene Name: TLX1
• UniProt Synonym Gene Names: HOX11; TCL3
• UniProt Entry Name: TLX1_HUMAN

NCBI Description

This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

Uniprot Description

TLX1: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Oncoprotein

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: nucleus

Molecular Function: protein binding; protein heterodimerization activity; sequence-specific DNA binding

Biological Process: neuron differentiation; spleen development; organ formation; cell fate commitment; central nervous system development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter