Rabbit anti-Mouse TLR1 Polyclonal Antibody | anti-TLR1 antibody

TLR1, CT (Toll-like Receptor 1, Toll/Interleukin-1 Receptor-like Protein, CD281, TIL) (MaxLight 750)

Cat. Num. AAA6502859

• Reactivity: Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein G Affinity Chromatography.
• Synonyms: TLR1; Polyclonal Antibody; CT (Toll-like Receptor 1; Toll/Interleukin-1 Receptor-like Protein; CD281; TIL) (MaxLight 750); anti-TLR1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse TLR1.
• Purity/Purification: Purified by Protein G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

• Applicable Applications for anti-TLR1 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:50-1:100; FLISA: 1:1,000; WB: 1:100-1:500; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the C-terminal region of mouse TLR1 (KLH).
• Conjugate: MaxLight750
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-TLR1 antibody

Antibodies; Toll Like Receptors (TLR)

References

1. Hajjar, A.M., et al., J. Immunol. 166(1):15-19 (2001). 2. Ozinsky, A., et al., Proc. Natl. Acad. Sci. USA 97(25):13766-13771 (2000).

NCBI and Uniprot Product Information

• NCBI GI #: 449784903
• NCBI GeneID: 21897
• NCBI Accession #: NP_001263374.1
• NCBI GenBank Nucleotide #: NM_001276445.1
• UniProt Accession #: Q9EPQ1; Q9EPW5
• Molecular Weight: 90,673 Da
• NCBI Official Full Name: toll-like receptor 1
• NCBI Official Synonym Full Names: toll-like receptor 1
• NCBI Official Symbol: Tlr1
• NCBI Protein Information: toll-like receptor 1
• UniProt Protein Name: Toll-like receptor 1
• Protein Family: Toll-like receptor
• UniProt Gene Name: Tlr1
• UniProt Synonym Gene Names: TIL

Uniprot Description

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (). Acts as a coreceptor for M.tuberculosis lipoproteins LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR2 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712).