Rabbit TLR1 Polyclonal Antibody | anti-TLR1 antibody
TLR1 Antibody BIOTIN-Conjugated
Predicted: Human
Predicted: Human
Immunocytochemistry: 1:100
Immunofluorescence: 1:100
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500
Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.
NCBI and Uniprot Product Information
Uniprot Description
TLR1: Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Binds MYD88 (via TIR domain). Interacts with CNPY3. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. Belongs to the Toll-like receptor family.
Protein type: Membrane protein, integral
Cellular Component: cytoplasmic vesicle; Golgi apparatus; integral to membrane; integral to plasma membrane; lipid raft; membrane; phagocytic vesicle; plasma membrane
Molecular Function: protein heterodimerization activity; transmembrane receptor activity; triacylated lipoprotein binding
Biological Process: activation of NF-kappaB-inducing kinase; defense response; defense response to bacterium; detection of triacylated bacterial lipoprotein; immune response; immune system process; inflammatory response; innate immune response; macrophage activation; microglial cell activation; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-6 biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; regulation of cytokine secretion; response to bacterial lipoprotein; signal transduction; toll-like receptor 1 signaling pathway; toll-like receptor signaling pathway
Research Articles on TLR1
Similar Products
Product Notes
The TLR1 tlr1 (Catalog #AAA5400089) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TLR1 Antibody BIOTIN-Conjugated reacts with Mouse, Rat Predicted: Human and may cross-react with other species as described in the data sheet. AAA Biotech's TLR1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). ELISA: 1:20,000 Immunocytochemistry: 1:100 Immunofluorescence: 1:100 Immunohistochemistry: 1:100 Immunoprecipitation: 1:200 Western Blot: 1:500. Researchers should empirically determine the suitability of the TLR1 tlr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TLR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
