Rabbit anti-Human TLL2 Polyclonal Antibody | anti-TLL2 antibody

TLL2, NT (Tolloid-like Protein 2, KIAA0932) (APC)

Cat. Num. AAA6502840

• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Ammonium Sulfate Precipitation.
• Synonyms: TLL2; Polyclonal Antibody; NT (Tolloid-like Protein 2; KIAA0932) (APC); anti-TLL2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human TLL2.
• Purity/Purification: Purified by Ammonium Sulfate Precipitation.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
• Sequence Length: 1015

• Applicable Applications for anti-TLL2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:50-1:100; ELISA: 1:1000; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide corresponding to a portion of amino acids within aa31-61 from the N-terminal region of human TLL2.
• Conjugate: APC
• Note: Preservative Free
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TLL2 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TLL2 antibody detected the TLL2 protein (arrow).)

Western Blot (WB)

(Western blot analysis of TLL2 (arrow) using rabbit polyclonal TLL2 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the TLL2 gene.)

Immunohistochemistry (IHC)

(TLL2 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TLL2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Product Categories/Family for anti-TLL2 antibody

Antibodies; Proteins

References

1. Scott, I.C., Dev. Biol. 213(2), 283-300 (1999).

NCBI and Uniprot Product Information

• NCBI GI #: 6912724
• NCBI GeneID: 7093
• NCBI Accession #: NP_036597
• NCBI GenBank Nucleotide #: NP_036597.1
• UniProt Accession #: Q9Y6L7
• Molecular Weight: 113.426
• NCBI Official Full Name: tolloid-like protein 2
• NCBI Official Synonym Full Names: tolloid like 2
• NCBI Official Symbol: TLL2
• NCBI Protein Information: tolloid-like protein 2
• UniProt Protein Name: Tolloid-like protein 2
• Protein Family: Tolloid-like protein
• UniProt Gene Name: TLL2
• UniProt Synonym Gene Names: KIAA0932
• UniProt Entry Name: TLL2_HUMAN

NCBI Description

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008]

Uniprot Description

TLL2: Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. Belongs to the peptidase M12A family.

Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.24.-

Chromosomal Location of Human Ortholog: 10q23-q24

Cellular Component: extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; multicellular organismal development; proteolysis; cell differentiation