Rabbit anti-Human TLL2 Polyclonal Antibody | anti-TLL2 antibody

TLL2, ID (TLL2, KIAA0932, Tolloid-like protein 2) (Biotin)

Cat. Num. AAA6355846

• Reactivity: Human
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
• Synonyms: TLL2; Polyclonal Antibody; ID (TLL2; KIAA0932; Tolloid-like protein 2) (Biotin); Tolloid-like protein 2; anti-TLL2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-TLL2 antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: IHC: 1:50-100; ELISA: 1:1,000; WB: 1:50-100; Applications are based on unconjugated antibody.
• Immunogen: TLL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-336 amino acids from the Central region of human TLL2.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TLL2 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the TLL2 antibody detected the TLL2 protein (arrow).)

Immunohistochemistry (IHC)

(TLL2 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TLL2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-TLL2 antibody

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin.

Product Categories/Family for anti-TLL2 antibody

Antibodies; KIAA; orf

References

Mac Sweeney, A., et al. J. Mol. Biol. 384(1):228-239(2008). Lesch, K.P., et al. J Neural Transm 115(11):1573-1585(2008). Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006). Deloukas, P., et al. Nature 429(6990):375-381(2004). Uzel, M.I., et al. J. Biol. Chem. 276(25):22537-22543(2001).

NCBI and Uniprot Product Information

• NCBI GI #: 6912724
• NCBI GeneID: 7093
• NCBI Accession #: NP_036597.1
• NCBI GenBank Nucleotide #: NM_012465.3
• UniProt Accession #: Q9Y6L7; Q2M1H1; Q6PJN5; Q9UQ00; A6NDK0
• Molecular Weight: 113,557 Da
• NCBI Official Full Name: tolloid-like protein 2
• NCBI Official Synonym Full Names: tolloid-like 2
• NCBI Official Symbol: TLL2
• NCBI Protein Information: tolloid-like protein 2
• UniProt Protein Name: Tolloid-like protein 2
• Protein Family: Tolloid-like protein
• UniProt Gene Name: TLL2
• UniProt Synonym Gene Names: KIAA0932
• UniProt Entry Name: TLL2_HUMAN

NCBI Description

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008]

Uniprot Description

TLL2: Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. Belongs to the peptidase M12A family.

Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.24.-

Chromosomal Location of Human Ortholog: 10q23-q24

Cellular Component: extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; multicellular organismal development; proteolysis; cell differentiation