Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cell using TLK2 antibody. Blue: DAPI for nuclear staining.)
Rabbit TLK2 Polyclonal Antibody | anti-TLK2 antibody
TLK2 antibody
Immunofluorescence: 1:50 - 1:100
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cell using TLK2 antibody. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cell using TLK2 antibody. Blue: DAPI for nuclear staining.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using TLK2 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using TLK2 antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Description
TLK2: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, Other; Kinase, protein; Other group; TLK family
Chromosomal Location of Human Ortholog: 17q23
Cellular Component: perinuclear region of cytoplasm; intermediate filament; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: negative regulation of autophagy; peptidyl-serine phosphorylation; regulation of chromatin assembly or disassembly; chromatin modification; cell cycle; protein amino acid phosphorylation; response to DNA damage stimulus; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; chromosome segregation
Research Articles on TLK2
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Product Notes
The TLK2 tlk2 (Catalog #AAA9403670) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TLK2 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TLK2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Western blotting: 1:500 - 1:2000 Immunofluorescence: 1:50 - 1:100. Researchers should empirically determine the suitability of the TLK2 tlk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TLK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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