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Western Blot (WB) (Western blot analysis of anti-TLK2 Antibody (Center) in mouse testis tissue lysates (35ug/lane).TLK2(arrow) was detected using the purified Pab.)

Rabbit anti-Human TLK2 Polyclonal Antibody | anti-TLK2 antibody

TLK2, ID (Serine/Threonine-protein Kinase Tousled-like 2, Tousled-like Kinase 2, PKU-alpha)

Gene Names
TLK2; MGC44450; PKU-ALPHA
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Affinity Purified
Purified by Protein G affinity chromatography.
Synonyms
TLK2; Polyclonal Antibody; ID (Serine/Threonine-protein Kinase Tousled-like 2; Tousled-like Kinase 2; PKU-alpha); Anti -TLK2; anti-TLK2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human TLK2.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Applicable Applications for anti-TLK2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunogen
Synthetic peptide selected from the center region of human TLK2 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of anti-TLK2 Antibody (Center) in mouse testis tissue lysates (35ug/lane).TLK2(arrow) was detected using the purified Pab.)

Western Blot (WB) (Western blot analysis of anti-TLK2 Antibody (Center) in mouse testis tissue lysates (35ug/lane).TLK2(arrow) was detected using the purified Pab.)

Western Blot (WB)

(TLK2 Antibody (K155) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the TLK2 antibody detected the TLK2 protein (arrow).)

Western Blot (WB) (TLK2 Antibody (K155) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the TLK2 antibody detected the TLK2 protein (arrow).)
Related Product Information for anti-TLK2 antibody
TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.
Product Categories/Family for anti-TLK2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
87,661 Da
NCBI Official Full Name
TLK2 protein
NCBI Official Synonym Full Names
tousled-like kinase 2
NCBI Official Symbol
TLK2
NCBI Official Synonym Symbols
MGC44450; PKU-ALPHA
NCBI Protein Information
serine/threonine-protein kinase tousled-like 2; serine/threonine kinase
UniProt Protein Name
Serine/threonine-protein kinase tousled-like 2
UniProt Gene Name
TLK2
UniProt Entry Name
TLK2_HUMAN

NCBI Description

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM]

Uniprot Description

TLK2: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; TLK family

Chromosomal Location of Human Ortholog: 17q23

Cellular Component: perinuclear region of cytoplasm; intermediate filament; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding

Biological Process: negative regulation of autophagy; peptidyl-serine phosphorylation; regulation of chromatin assembly or disassembly; chromatin modification; cell cycle; protein amino acid phosphorylation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; response to DNA damage stimulus; chromosome segregation

Research Articles on TLK2

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Product Notes

The TLK2 tlk2 (Catalog #AAA626320) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TLK2, ID (Serine/Threonine-protein Kinase Tousled-like 2, Tousled-like Kinase 2, PKU-alpha) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TLK2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: ELISA: 1:1,000 Western Blot: 1:100-1:500. Researchers should empirically determine the suitability of the TLK2 tlk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TLK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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