Rabbit anti-Human, Mouse TIP30 Polyclonal Antibody | anti-HTATIP2 antibody

TIP30 Antibody

Cat. Num. AAA9629349

• Gene Names: HTATIP2; CC3; TIP30; SDR44U1
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: TIP30; Polyclonal Antibody; TIP30 Antibody; 30 kDa HIV 1 TAT interacting protein; 30 kDa HIV-1 TAT-interacting protein; 30 kDa HIV1 TAT interacting protein; CC3; FLJ26963; HIV 1 Tat interacting protein 2 30kDa; HIV 1 Tat interacting protein 2; HIV-1 TAT-interactive protein 2; HTAI2_HUMAN; HTATIP 2; HTATIP2; Oxidoreductase HTATIP2; SDR44U1; Short chain dehydrogenase/reductase family 44U member 1; Tat interacting protein (30kDa); anti-HTATIP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: TIP30 Antibody detects endogenous levels of total TIP30.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-HTATIP2 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: Unique C-terminus confers high proteasome-dependent instability to isoform 2.
• Subunit Structure: Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA. Isoform 2 binds the proteasome subunit PSMD4/s5a through its N-terminus.(Microbial infection) Interacts with HIV-1 Tat (via activation domain).
• Tissue Specificity: Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas.
• Function: Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-HTATIP2 antibody

Cytoplasm; Nucleus envelope; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 148728166
• NCBI GeneID: 10553
• NCBI Accession #: NP_001091990.1
• NCBI GenBank Nucleotide #: NM_001098520.1
• UniProt Accession #: Q9BUP3; O15383; O60520; O95345; Q53GC1; Q53GG2; Q6IBI3; A8K7S7; D3DQY8
• Molecular Weight: 30,131 Da
• NCBI Official Full Name: oxidoreductase HTATIP2 isoform a
• NCBI Official Synonym Full Names: HIV-1 Tat interactive protein 2, 30kDa
• NCBI Official Symbol: HTATIP2
• NCBI Official Synonym Symbols: CC3; TIP30; SDR44U1
• NCBI Protein Information: oxidoreductase HTATIP2; 30 kDa HIV-1 TAT-interacting protein; HIV-1 TAT-interactive protein 2; Tat-interacting protein (30kD); short chain dehydrogenase/reductase family 44U, member 1
• UniProt Protein Name: Oxidoreductase HTATIP2
• Protein Family: Oxidoreductase
• UniProt Gene Name: HTATIP2
• UniProt Entry Name: HTAI2_HUMAN

Uniprot Description

HTATIP2: Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.1.1.-; Nuclear envelope; Transcription factor; Apoptosis; Tumor suppressor; Oxidoreductase

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: membrane; cytoplasm; nuclear envelope; nucleus

Molecular Function: protein binding; transcription coactivator activity; oxidoreductase activity

Biological Process: regulation of transcription from RNA polymerase II promoter; viral reproduction; apoptosis; nuclear import; angiogenesis; cell differentiation; regulation of angiogenesis; negative regulation of apoptosis