Rabbit anti-Human TIMP1 TIMP1 Polyclonal Antibody | anti-TIMP1 antibody
TIMP1 antibody
Reactivity
Human TIMP1
Applications
ELISA, Western Blot
Synonyms
TIMP1; Polyclonal Antibody; TIMP1 antibody; Polyclonal TIMP1; Anti-TIMP1; TIMP 1; TIMP-1; Tissue inhibitor of metalloantibodyases: Fibroblast collagenase inhibitor; Erythroid-potentiating activity; anti-TIMP1 antibody
Host
Rabbit
Reactivity
Human TIMP1
Clonality
Polyclonal
Specificity
Human TIMP1
Form/Format
Lyophilized from PBS, pH 7.2.
Sequence Length
207
Applicable Applications for anti-TIMP1 antibody
ELISA (EIA), Inhibition, Western Blot (WB)
Application Notes
ELISA: 0.5-2 ug/ml
Inhibition: 5 ug/ml
WB: 0.1-0.2 ug/ml
Inhibition: 5 ug/ml
WB: 0.1-0.2 ug/ml
Biological Significance
TIMP1 is an extracellular inhibitor of MMPs (see above) including MMP1, 2, 3, 7, 8, 9, 10, 11, 12, 13, and 16. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP1 can also act through an MMP-independent mechanism to promote erythropoiesis by stimulating proliferation and differentiation of erythroid progenitors.
Immunogen
TIMP1 antibody was raised in rabbit using highly pure recombinant human TIMP-1 as the immunogen.
Preparation and Storage
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
Related Product Information for anti-TIMP1 antibody
Affinity purified Rabbit polyclonal TIMP1 antibody
Product Categories/Family for anti-TIMP1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
20.6 kDa (predicted detection band MW)
NCBI Official Full Name
TIMP-1
NCBI Official Symbol
TIMP1
NCBI Protein Information
metalloproteinase inhibitor 1
UniProt Protein Name
Metalloproteinase inhibitor 1
Protein Family
UniProt Gene Name
TIMP1
UniProt Synonym Gene Names
EG-1; TIMP-1
UniProt Entry Name
TIMP1_BOVIN
Uniprot Description
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling.
Research Articles on TIMP1
Similar Products
Product Notes
The TIMP1 timp1 (Catalog #AAA535728) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TIMP1 antibody reacts with Human TIMP1 and may cross-react with other species as described in the data sheet. AAA Biotech's TIMP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Inhibition, Western Blot (WB). ELISA: 0.5-2 ug/ml Inhibition: 5 ug/ml WB: 0.1-0.2 ug/ml. Researchers should empirically determine the suitability of the TIMP1 timp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIMP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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