Rabbit TIMM8A Polyclonal Antibody | anti-TIMM8A antibody

TIMM8A Antibody

Cat. Num. AAA9430245

• Gene Names: TIMM8A; DDP; MTS; DDP1; DFN1; TIM8
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: TIMM8A; Polyclonal Antibody; TIMM8A Antibody; DDP; MTS; DDP1; DFN1; TIM8; anti-TIMM8A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: The antibody detects endogenous levels of total TIMM8A protein.
• Purity/Purification: Antigen affinity purification
• Form/Format: pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 1.6 mg/mL (varies by lot)
• Sequence Length: 97

• Applicable Applications for anti-TIMM8A antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-300
• Immunogen: Fusion protein of human TIMM8A
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C.

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 47262(TIMM8A Antibody) at dilution 1/90.(Original magnification: 200))

Related Product Information for anti-TIMM8A antibody

This translocase is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Product Categories/Family for anti-TIMM8A antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4758152
• NCBI GeneID: 1678
• NCBI Accession #: NP_004076.1
• NCBI GenBank Nucleotide #: NM_004085.4
• UniProt Accession #: O60220; Q6IRW6; B2R5A6
• Molecular Weight: 10,998 Da
• NCBI Official Full Name: mitochondrial import inner membrane translocase subunit Tim8 A isoform 1
• NCBI Official Synonym Full Names: translocase of inner mitochondrial membrane 8A
• NCBI Official Symbol: TIMM8A
• NCBI Official Synonym Symbols: DDP; MTS; DDP1; DFN1; TIM8
• NCBI Protein Information: mitochondrial import inner membrane translocase subunit Tim8 A
• UniProt Protein Name: Mitochondrial import inner membrane translocase subunit Tim8 A
• Protein Family: Mitochondrial import inner membrane translocase
• UniProt Gene Name: TIMM8A
• UniProt Synonym Gene Names: DDP; DDP1; TIM8A

NCBI Description

This translocase is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2009]

Uniprot Description

Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.