Rabbit anti-Human TICAM1 Polyclonal Antibody | anti-TICAM1 antibody

TICAM1, CT (TIR Domain-containing Adapter Molecule 1, TICAM-1, Proline-rich, Vinculin and TIR Domain-containing Protein B, Putative NF-kappa-B-activating Protein 502H, Toll-interleukin-1 Receptor Domain-containing Adapter Protein Inducing Interferon beta,

Cat. Num. AAA646162

• Gene Names: TICAM1; TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Purified; Purified
• Synonyms: TICAM1; Polyclonal Antibody; CT (TIR Domain-containing Adapter Molecule 1; TICAM-1; Proline-rich; Vinculin and TIR Domain-containing Protein B; Putative NF-kappa-B-activating Protein 502H; Toll-interleukin-1 Receptor Domain-containing Adapter Protein Inducing Interferon beta; ; Anti -TICAM1; anti-TICAM1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human TICAM1.
• Purity/Purification: Purified; Purified
• Form/Format: Supplied as a liquid in PBS, 0.2% sodium azide.

• Applicable Applications for anti-TICAM1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
• Immunogen: Synthetic peptide corresponding to 14aa of human TICAM1, at C-terminal (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Heart (formalin-fixed, paraffin-embedded) stained with TICAM1 antibody at 10ug/ml followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-TICAM1 antibody

TRIF is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TRIF, along with other molecules such as TIRP, TIRAP, and MyD88, serves as an adaptor protein to several of the TLR molecules. Following activation of TLR3 and TLR4, TRIF engages the kinase TBK1 and allows its subsequent activation of the interferon regulatory factor (IRF)-3. TRIF is also involved in the activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kB.

Product Categories/Family for anti-TICAM1 antibody

Antibodies; Abs to Adapter Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 41281981
• NCBI GeneID: 148022
• NCBI Accession #: NP_891549.1
• NCBI GenBank Nucleotide #: NM_182919.3
• UniProt Accession #: Q8IUC6; O75532; Q86XP8; Q96GA0; B3Y691
• Molecular Weight: 76,422 Da
• NCBI Official Full Name: TIR domain-containing adapter molecule 1
• NCBI Official Synonym Full Names: toll-like receptor adaptor molecule 1
• NCBI Official Symbol: TICAM1
• NCBI Official Synonym Symbols: TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1
• NCBI Protein Information: TIR domain-containing adapter molecule 1; putative NF-kappa-B-activating protein 502H; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter protein inducing IFN-beta; proline-rich, vinculin and TIR domain-containing protein B; toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
• UniProt Protein Name: TIR domain-containing adapter molecule 1
• Protein Family: TIR domain-containing adapter molecule
• UniProt Gene Name: TICAM1
• UniProt Synonym Gene Names: PRVTIRB; TRIF; TICAM-1; MyD88-3
• UniProt Entry Name: TCAM1_HUMAN

NCBI Description

This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]

Uniprot Description

Function: Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Ref.1 Ref.2 Ref.11

Subunit structure: Homodimer

Probable. Interacts (via the TIR domain) with TLR3; mediates TLR3 signaling. Interacts with AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3

By similarity. Interacts with TRAF6. Interacts with TRAFD1

By similarity. Ref.1 Ref.2 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14

Tissue specificity: Ubiquitously expressed but with higher levels in liver. Ref.1 Ref.2

Domain: The N-terminal region is essential for activation of the IFNB promoter activity. Ref.1 Ref.2 Ref.11

Post-translational modification: Phosphorylated by TBK1. Ref.9

Involvement in disease: Herpes simplex encephalitis 4 (HSE4) [MIM:614850]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.18

Sequence similarities: Contains 1 TIR domain.

Sequence caution: The sequence AAO85488.1 differs from that shown. Reason: Frameshift at positions 141, 148 and 161.