Goat THRSP Polyclonal Antibody | anti-THRSP antibody

Goat Polyclonal to Human THRSP

Cat. Num. AAA242761

• Gene Names: THRSP; S14; Lpgp; THRP; LPGP1; SPOT14
• Reactivity: Human; Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: THRSP; Polyclonal Antibody; Goat Polyclonal to Human THRSP; Anti-THRSP Antibody IHC-plus; Lpgp; Lipogenic protein 1; S14; SPOT14; THRP; SPOT14 homolog; LPGP1; Spot 14 protein; Thyroid hormone responsive; Human THRSP; anti-THRSP antibody

• Host: Goat
• Reactivity: Human; Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human THRSP.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 146

• Applicable Applications for anti-THRSP antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (3.75 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide from human THRSP. Percent identity with other species by BLAST analysis: Human (100%), Gorilla (93%), Monkey (86%).
• Immunogen: THRSP antibody was raised against synthetic peptide from human THRSP. Percent identity with other species by BLAST analysis: Human (100%), Gorilla (93%), Monkey (86%).
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-THRSP antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-THRSP antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Related Product Information for anti-THRSP antibody

S14 (Thyroid Hormone Inducible Hepatic Protein) is a nuclear protein communicates the status of dietary fuels and fuel-related hormones to genes required for long-chain fatty acid synthesis. In mammary glands S14 is important for both epithelial proliferation and milk fat production. High expression of S14 in primary invasive breast cancer is predicative of recurrence. S14 also medicates the induction of lipogenesis by protestin in breast cancer cells and accelerates their growth.

NCBI and Uniprot Product Information

• NCBI GI #: 4507497
• NCBI GeneID: 7069
• NCBI Accession #: NP_003242.1
• NCBI GenBank Nucleotide #: NM_003251.3
• UniProt Accession #: Q92748; B2R4W7
• Molecular Weight: 16,561 Da
• NCBI Official Full Name: thyroid hormone-inducible hepatic protein
• NCBI Official Synonym Full Names: thyroid hormone responsive
• NCBI Official Symbol: THRSP
• NCBI Official Synonym Symbols: S14; Lpgp; THRP; LPGP1; SPOT14
• NCBI Protein Information: thyroid hormone-inducible hepatic protein; SPOT14 homolog; spot 14 protein; lipogenic protein 1; thyroid hormone responsive SPOT14; thyroid hormone responsive (SPOT14 homolog, rat)
• UniProt Protein Name: Thyroid hormone-inducible hepatic protein
• Protein Family: Thyroid hormone-inducible hepatic protein
• UniProt Gene Name: THRSP
• UniProt Synonym Gene Names: S14; SPOT14
• UniProt Entry Name: THRSP_HUMAN

NCBI Description

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]

Uniprot Description

THRSP: Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB. Belongs to the SPOT14 family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 11q14.1

Cellular Component: nucleoplasm; cytosol

Molecular Function: protein homodimerization activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; lipid metabolic process; regulation of lipid biosynthetic process