Goat thromboxane A2 receptor Polyclonal Antibody | anti-TBXA2R antibody

Goat Anti-thromboxane A2 receptor (isoform beta) Antibody

Cat. Num. AAA423666

• Gene Names: TBXA2R; TXA2-R; BDPLT13
• Reactivity: Human; Tested: Human; Expected from sequence similarity: Human
• Applications: ELISA, Western Blot
• Purity: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Synonyms: thromboxane A2 receptor; Polyclonal Antibody; Goat Anti-thromboxane A2 receptor (isoform beta) Antibody; TBXA2R antibody; thromboxane A2 receptor antibody; BDPLT13 antibody; TXA2-R antibody; prostanoid TP receptor antibody; anti-TBXA2R antibody

• Host: Goat
• Reactivity: Human; Tested: Human; Expected from sequence similarity: Human
• Clonality: Polyclonal
• Purity/Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Form/Format: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Sequence: PFEPPTGKALSRKD
• Sequence Length: 407

• Applicable Applications for anti-TBXA2R antibody: Peptide ELISA (EIA), Western Blot (WB)
• Application Notes: Western Blot: Approx 55kDa band observed in Human Lung and Placenta lysates (calculated MW of 44.2kDa according to NP_963998.2). The observed molecular weight corresponds to the glycosylated form. Recommended concentration: 0.03-0.1ug/ml.; Peptide ELISA: Antibody detection limit dilution 1:128000.
• Immunogen: Peptide with sequence C-PFEPPTGKALSRKD, from the C Terminus of the protein sequence according to NP_963998.2.
• Epitope: C Terminus
• Note: This antibody is expected to recognize the reported isoform beta (NP_963998.2) only.
• Preparation and Storage: Aliquot and store at -20 degree C. Minimize freezing and thawing.

Western Blot (WB)

((0.03ug/ml) staining of Human Lung lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

NCBI and Uniprot Product Information

• NCBI GI #: 260593681
• NCBI GeneID: 6915
• NCBI Accession #: NP_963998.2
• NCBI GenBank Nucleotide #: NM_201636.2
• Molecular Weight: 44,205 Da
• NCBI Official Full Name: thromboxane A2 receptor isoform beta
• NCBI Official Synonym Full Names: thromboxane A2 receptor
• NCBI Official Symbol: TBXA2R
• NCBI Official Synonym Symbols: TXA2-R; BDPLT13
• NCBI Protein Information: thromboxane A2 receptor
• UniProt Protein Name: Thromboxane A2 receptor
• Protein Family: Thromboxane A2 receptor
• UniProt Gene Name: TBXA2R
• UniProt Synonym Gene Names: TXA2-R
• UniProt Entry Name: TA2R_HUMAN

NCBI Description

This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Description

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.