Rabbit anti-Human Thrombopoietin Receptor Polyclonal Antibody | anti-TPOR antibody

Thrombopoietin Receptor (TPO-R, Myeloproliferative Leukemia Protein, Proto-oncogene c-Mpl, CD110, TPOR) (PE)

Cat. Num. AAA6502537

• Gene Names: MPL; MPLV; TPOR; C-MPL; CD110; THCYT2
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified
• Synonyms: Thrombopoietin Receptor; Polyclonal Antibody; Thrombopoietin Receptor (TPO-R; Myeloproliferative Leukemia Protein; Proto-oncogene c-Mpl; CD110; TPOR) (PE); anti-TPOR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MPL.
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-TPOR antibody: Western Blot (WB)
• Application Notes: For maximum recovery of product, 11c7entrifuge the original vial after thawing and prior to removing the cap.; Applications are based on unconjugated antibody.
• Immunogen: MPL (NP_005364.1, 1-635aa) full-length human protein.
• Conjugate: PE
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-TPOR antibody

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635aa transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Product Categories/Family for anti-TPOR antibody

Antibodies; Thrombopoietin

NCBI and Uniprot Product Information

• NCBI GI #: 4885491
• NCBI GeneID: 4352
• NCBI Accession #: NP_005364.1
• NCBI GenBank Nucleotide #: NM_005373.2
• Molecular Weight: 65,521 Da
• NCBI Official Full Name: thrombopoietin receptor
• NCBI Official Synonym Full Names: MPL proto-oncogene, thrombopoietin receptor
• NCBI Official Symbol: MPL
• NCBI Official Synonym Symbols: MPLV; TPOR; C-MPL; CD110; THCYT2
• NCBI Protein Information: thrombopoietin receptor; TPO-R; proto-oncogene c-Mpl; myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene
• Protein Family: Thrombopoietin receptor

NCBI Description

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]