Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/25,)
Rabbit anti-Human THEM5 Polyclonal Antibody | anti-THEM5 antibody
THEM5 Antibody
Gene Names
THEM5; ACOT15
Reactivity
Human
Applications
Immunohistochemistry
Purity
Antigen Affinity Purification
Synonyms
THEM5; Polyclonal Antibody; THEM5 Antibody; ACOT15; anti-THEM5 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total THEM5 protein.
Purity/Purification
Antigen Affinity Purification
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
0.4 mg/ml (varies by lot)
Sequence Length
247
Applicable Applications for anti-THEM5 antibody
Immunohistochemistry (IHC)
Application Notes
Immunohistochemistry: 1:10-1:50
Immunogen
Full length fusion protein of human THEM5
Immunogen Type
Protein
Preparation and Storage
Store at -20 degree C
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/25,)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/25,)
Related Product Information for anti-THEM5 antibody
THEM5 (thioesterase superfamily member 5) is a 247 amino acid protein that belongs to the thioesterase superfamily. The gene that encodes THEM5 contains nearly 8,000 bases and maps to human chromosome 1q21.3. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function.
Product Categories/Family for anti-THEM5 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
27,677 Da
NCBI Official Full Name
acyl-coenzyme A thioesterase THEM5
NCBI Official Synonym Full Names
thioesterase superfamily member 5
NCBI Official Symbol
THEM5
NCBI Official Synonym Symbols
ACOT15
NCBI Protein Information
acyl-coenzyme A thioesterase THEM5
UniProt Protein Name
Acyl-coenzyme A thioesterase THEM5
Protein Family
UniProt Gene Name
THEM5
UniProt Synonym Gene Names
ACOT15; Acyl-CoA thioesterase THEM5
UniProt Entry Name
ACO15_HUMAN
Uniprot Description
THEM5: Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function. Belongs to the THEM4/THEM5 thioesterase family. Homodimer
Protein type: EC 3.1.2.2
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: mitochondrial matrix
Molecular Function: acyl-CoA hydrolase activity; palmitoyl-CoA hydrolase activity; protein binding
Similar Products
Product Notes
The THEM5 them5 (Catalog #AAA9415754) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The THEM5 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's THEM5 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:10-1:50. Researchers should empirically determine the suitability of the THEM5 them5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "THEM5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
