Immunohistochemistry (IHC)
(Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit THBD/CD141/Thrombomodulin Polyclonal Antibody | anti-THBD antibody
Anti-THBD/CD141/Thrombomodulin Antibody (C-Terminus)
Gene Names
THBD; TM; THRM; AHUS6; BDCA3; CD141; THPH12
Reactivity
HumanPredicted: Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Purity
Immunoaffinity Purified
Synonyms
THBD/CD141/Thrombomodulin; Polyclonal Antibody; Anti-THBD/CD141/Thrombomodulin Antibody (C-Terminus); Rat Monoclonal [clone 461714] (IgG2b) to Mouse THBD/CD141/Thrombomodulin; THBD; BDCA3; CD141 antigen; CD141; AHUS6; Fetomodulin; THPH12; TM; THRM; Thrombomodulin; anti-THBD antibody
Host
Rabbit
Reactivity
Human
Predicted: Mouse, Rat
Predicted: Mouse, Rat
Clonality
Polyclonal
Specificity
Recognizes endogenous levels of CD141 protein.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, pH 7.3, 0.01% sodium azide, 30% glycerol.
Sequence Length
575
Applicable Applications for anti-THBD antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes
IHC-P: 1:50
WB: 1:500-1:1000
WB: 1:500-1:1000
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-terminal region of human CD141.
Conjugation
Unconjugated
Epitope
C-Terminus
Preparation and Storage
Store at -20 degree C.
Aliquot to avoid freeze/thaw cycles.
Aliquot to avoid freeze/thaw cycles.
Immunohistochemistry (IHC)
(Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry (IHC)
(Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE))
Western Blot (WB)
(Western blot analysis of CD141 expression in HEK293T (A); Raw264.7 (B); PC12 (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of CD141 expression in HEK293T (A); Raw264.7 (B); PC12 (C) whole cell lysates.)
Related Product Information for anti-THBD antibody
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1stoichiometric complex with thrombin. This complex is responsible forthe conversion of protein C to the activated protein C (protein Ca).Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reducesthe amount of thrombin generated.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
60,329 Da
NCBI Official Full Name
thrombomodulin
NCBI Official Synonym Full Names
thrombomodulin
NCBI Official Symbol
THBD
NCBI Official Synonym Symbols
TM; THRM; AHUS6; BDCA3; CD141; THPH12
NCBI Protein Information
thrombomodulin
UniProt Protein Name
Thrombomodulin
Protein Family
UniProt Gene Name
THBD
UniProt Synonym Gene Names
THRM; TM
NCBI Description
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
Uniprot Description
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Research Articles on THBD
Similar Products
Product Notes
The THBD thbd (Catalog #AAA2401446) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-THBD/CD141/Thrombomodulin Antibody (C-Terminus) reacts with Human Predicted: Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's THBD/CD141/Thrombomodulin can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB). IHC-P: 1:50 WB: 1:500-1:1000. Researchers should empirically determine the suitability of the THBD thbd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "THBD/CD141/Thrombomodulin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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