Western Blot (WB)
(TGIF2 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TGIF2 antibody detected the TGIF2 protein (arrow).)
Rabbit anti-Human TGIF2 Polyclonal Antibody | anti-TGIF2 antibody
TGIF2 Antibody (C-term)
Western Blot (WB)
(TGIF2 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TGIF2 antibody detected the TGIF2 protein (arrow).)
Western Blot (WB)
(TGIF2 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TGIF2 antibody detected the TGIF2 protein (arrow).)
Flow Cytometry (FC/FACS)
(TGIF2 Antibody (C-term) flow cytometric analysis of Neuro-2a cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(TGIF2 Antibody (C-term) flow cytometric analysis of Neuro-2a cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.)
protein and a transcriptional repressor. The encoded protein
appears to repress transcription by recruiting histone deacetylases
to TGF beta-responsive genes. This gene is amplified and
overexpressed in some ovarian cancers, and mutations in this gene
can cause holoprosencephaly.
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Melhuish, T.A., et al. J. Biol. Chem. 276(34):32109-32114(2001)
Imoto, I., et al. Biochem. Biophys. Res. Commun. 276(1):264-270(2000)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]
Uniprot Description
TGIF2: Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. Belongs to the TALE/TGIF homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 20q11.23
Cellular Component: nucleoplasm; centrosome; nucleus
Molecular Function: DNA binding; transcription factor activity
Biological Process: transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; regulation of transcription, DNA-dependent; retina development in camera-type eye; regulation of gastrulation; transforming growth factor beta receptor signaling pathway; gene expression; negative regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation
Research Articles on TGIF2
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Product Notes
The TGIF2 tgif2 (Catalog #AAA9208996) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 171-199. The TGIF2 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TGIF2 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB). WB~~1:1000. Researchers should empirically determine the suitability of the TGIF2 tgif2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TGIF2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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