Western Blot (WB)
(Western blot analysis of anti-TGFBR1 Pab in Jurkat cell line lysates (35ug/lane). TGFBR1 (arrow) was detected using the purified Pab.)
Rabbit TGF Beta Receptor I Polyclonal Antibody | anti-TGFBR1 antibody
TGF Beta Receptor I Antibody (Center)
Western Blot (WB)
(Western blot analysis of anti-TGFBR1 Pab in Jurkat cell line lysates (35ug/lane). TGFBR1 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of anti-TGFBR1 Pab in Jurkat cell line lysates (35ug/lane). TGFBR1 (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Uniprot Description
TGFBR1: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart.
Protein type: Protein kinase, TKL; Kinase, protein; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; Receptor, misc.; TKL group; STKR family; Type1 subfamily
Chromosomal Location of Human Ortholog: 9q22
Cellular Component: tight junction; membrane; cell; plasma membrane; receptor complex; endosome
Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; transforming growth factor beta binding; growth factor binding; metal ion binding; receptor signaling protein activity; punt binding; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity
Biological Process: blastocyst development; collagen fibril organization; activation of MAPKK activity; positive regulation of transcription, DNA-dependent; heart development; negative regulation of chondrocyte differentiation; activin receptor signaling pathway; cell motility involved in cell locomotion; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; extracellular structure organization and biogenesis; transforming growth factor beta receptor signaling pathway; germ cell migration; kidney development; cell cycle arrest; neuron fate commitment; embryonic cranial skeleton morphogenesis; positive regulation of cell growth; parathyroid gland development; endothelial cell activation; mesenchymal cell differentiation; regulation of gene expression; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of endothelial cell proliferation; lens development in camera-type eye; wound healing; apoptosis; regulation of protein ubiquitination; palate development; signal transduction; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; angiogenesis; skeletal development; positive regulation of filopodium formation; pharyngeal system development; thymus development; in utero embryonic development; male gonad development; peptidyl-threonine phosphorylation; positive regulation of cell motility; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; skeletal morphogenesis; regulation of protein binding; epithelial to mesenchymal transition; artery morphogenesis; negative regulation of transforming growth factor beta receptor signaling pathway
Disease: Multiple Self-healing Squamous Epithelioma, Susceptibility To
Research Articles on TGFBR1
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Product Notes
The TGFBR1 tgfbr1 (Catalog #AAA9213761) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 134-163. The TGF Beta Receptor I Antibody (Center) reacts with Human, mouse (Predicted Reactivity: Bovine, Pig, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's TGF Beta Receptor I can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the TGFBR1 tgfbr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TGF Beta Receptor I, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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