Goat anti-Human TFAP2C Polyclonal Antibody | anti-TFAP2C antibody

TFAP2C, CT (Transcription Factor AP-2 gamma, AP2-gamma, Activating Enhancer-binding Protein 2 gamma, Transcription Factor ERF-1)

Cat. Num. AAA641871

• Gene Names: TFAP2C; ERF1; TFAP2G; hAP-2g; AP2-GAMMA
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: TFAP2C; Polyclonal Antibody; CT (Transcription Factor AP-2 gamma; AP2-gamma; Activating Enhancer-binding Protein 2 gamma; Transcription Factor ERF-1); Anti -TFAP2C; anti-TFAP2C antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human TFAP2C. Species sequence homology: Canine, mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-TFAP2C antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:128,000; Immunohistochemistry (Formalin-fixed, paraffin-embedded): 2.5ug/ml
• Immunogen: Synthetic peptide corresponding to C-NKTLEKMEKHRK from the C-terminal of human TFAP2C.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Skin (formalin-fixed, paraffin-embedded) stained with TFAP2C antibody at 2.5ug/ml followed by biotinylated goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-TFAP2C antibody

Transcription factor gene AP2-C (AP-2 gamma) belongs to a family of four closely related genes. The AP-2 transcription factor has been shown to play an important role in the development of tissues of ectodermal origin and has also been implicated in mammary oncogenesis. A physical and functional association between AP-2gamma transcription factor and the Wwox protein has been demonstrated. results suggest that Wwox tumor suppressor protein inhibits AP-2gamma oncogenic activity by sequestering it in the cytoplasm. P-2 gamma had been implicated in multiple functions during proliferation and differentiation based on its expression pattern in trophoblast, neural crest, and ectoderm cells in murine embryos. AP-2 gamma seems to be required in early embryonic development because it regulates the genetic programs controlling proliferation and differentiation of extraembryonic trophectodermal cells.

Product Categories/Family for anti-TFAP2C antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 4507445
• NCBI GeneID: 7022
• NCBI Accession #: NP_003213.1
• NCBI GenBank Nucleotide #: NM_003222.3
• UniProt Accession #: Q92754; O00685; O00730; Q86V30; Q8IVB6; Q9P1X2
• Molecular Weight: 49,177 Da
• NCBI Official Full Name: transcription factor AP-2 gamma
• NCBI Official Synonym Full Names: transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
• NCBI Official Symbol: TFAP2C
• NCBI Official Synonym Symbols: ERF1; TFAP2G; hAP-2g; AP2-GAMMA
• NCBI Protein Information: transcription factor AP-2 gamma; estrogen receptor factor 1; transcription factor ERF-1; activating enhancer-binding protein 2 gamma; transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma)
• UniProt Protein Name: Transcription factor AP-2 gamma
• Protein Family: Transcription factor
• UniProt Gene Name: TFAP2C
• UniProt Synonym Gene Names: AP2-gamma
• UniProt Entry Name: AP2C_HUMAN

NCBI Description

The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]

Uniprot Description

AP-2 gamma: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. During retinoic acid-mediated differentiation. Belongs to the AP-2 family.

Protein type: DNA-binding; Transcription factor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: nucleus

Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; somatic stem cell maintenance; male gonad development; sebaceous gland development; germ-line stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; regulation of cell proliferation; trophectodermal cell differentiation; regulation of transcription from RNA polymerase II promoter; cell-cell signaling; hair follicle development; positive regulation of transcription from RNA polymerase II promoter; forebrain neuron fate commitment; cerebral cortex development; regulation of epidermis development