Rabbit anti-Human TERF2IP Polyclonal Antibody | anti-TERF2IP antibody

TERF2IP, CT (TERF2IP, DRIP5, RAP1, Telomeric repeat-binding factor 2-interacting protein 1, Dopamine receptor-interacting protein 5, Repressor/activator protein 1 homolog) (MaxLight 405)

Cat. Num. AAA6354826

• Gene Names: TERF2IP; RAP1; DRIP5
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TERF2IP; Polyclonal Antibody; CT (TERF2IP; DRIP5; RAP1; Telomeric repeat-binding factor 2-interacting protein 1; Dopamine receptor-interacting protein 5; Repressor/activator protein 1 homolog) (MaxLight 405); Repressor/activator protein 1 homolog; anti-TERF2IP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

• Applicable Applications for anti-TERF2IP antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: TERF2IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 348-378 amino acids from the C-terminal region of human TERF2IP.
• Conjugate: MaxLight405
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-TERF2IP antibody

The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22.

Product Categories/Family for anti-TERF2IP antibody

Antibodies; Binding Proteins

References

Teo, H., et al. Nat. Cell Biol. 12(8):758-767(2010). Martinez, P., et al. Nat. Cell Biol. 12(8):768-780(2010). Da-Silva, N., et al. Dig Liver Dis 42(8):544-548(2010). Bombarde, O., et al. EMBO J. 29(9):1573-1584(2010). Shen, J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):219-228(2010).

NCBI and Uniprot Product Information

• NCBI GI #: 52627149
• NCBI GeneID: 54386
• NCBI Accession #: NP_061848.2
• NCBI GenBank Nucleotide #: NM_018975.3
• UniProt Accession #: Q9NYB0; Q4W4Y2; Q8WYZ3; Q9NWR2; B4DQN4
• Molecular Weight: 44,260 Da
• NCBI Official Full Name: telomeric repeat-binding factor 2-interacting protein 1
• NCBI Official Synonym Full Names: telomeric repeat binding factor 2, interacting protein
• NCBI Official Symbol: TERF2IP
• NCBI Official Synonym Symbols: RAP1; DRIP5
• NCBI Protein Information: telomeric repeat-binding factor 2-interacting protein 1; hRap1; RAP1 homolog; TRF2-interacting telomeric protein 1; TERF2-interacting telomeric protein 1; repressor/activator protein 1 homolog; TRF2-interacting telomeric RAP1 protein; dopamine receptor in
• UniProt Protein Name: Telomeric repeat-binding factor 2-interacting protein 1
• Protein Family: Telomeric repeat-binding factor 2-interacting protein
• UniProt Gene Name: TERF2IP
• UniProt Synonym Gene Names: DRIP5; RAP1; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; RAP1 homolog; hRap1
• UniProt Entry Name: TE2IP_HUMAN

Uniprot Description

TERF2IP: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG. Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2; the interaction is direct. Does not interact with TERF1. Interacts with SLX4/BTBD12. Ubiquitous. Highly expressed. Belongs to the RAP1 family.

Protein type: DNA replication

Chromosomal Location of Human Ortholog: 16q23.1

Cellular Component: nucleoplasm; nuclear chromosome; chromosome, telomeric region; nuclear telomere cap complex; Mre11 complex; nuclear chromosome, telomeric region; cytoplasm; nuclear envelope; nucleus

Molecular Function: protein binding; telomeric DNA binding

Biological Process: negative regulation of telomere maintenance; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of DNA recombination at telomere; telomere maintenance via telomerase; positive regulation of peptidyl-serine phosphorylation; telomere maintenance; activation of NF-kappaB transcription factor; protection from non-homologous end joining at telomere