Rabbit Telomerase-Associated Protein 1 Polyclonal Antibody | anti-TEP1 antibody

Telomerase-Associated Protein 1 (TEP1, P240, TLP1, TP1, Tp-1, TROVE1, VAULT2)

Cat. Num. AAA622636

• Gene Names: TEP1; TP1; TLP1; p240; TROVE1; VAULT2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Synonyms: Telomerase-Associated Protein 1; Polyclonal Antibody; Telomerase-Associated Protein 1 (TEP1; P240; TLP1; TP1; Tp-1; TROVE1; VAULT2); Anti -Telomerase-Associated Protein 1 (TEP1; anti-TEP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Recognizes Human Telomerase-associated Protein Tp-1 (TEP1). Species Crossreactivity: Human, Mouse, Rat.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-TEP1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Immunohistochemistry: 5ug/ml
• Immunogen: Synthetic peptide, KLH-conjugated. Epitope: 20 amino acid peptide from near the amino terminus of human TP1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Immunohistochemistry (IHC)

(TEP1 (5ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human breast, followed by biotinylated goat rabbit IgG secondary, alkaline phosphatase-streptavidin and chromogen.)

Immunohistochemistry (IHC)

(TEP1 (5ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human skin, followed by biotinylated goat rabbit IgG secondary, alkaline phosphatase-streptavidin and chromogen.)

Product Categories/Family for anti-TEP1 antibody

Antibodies; Abs to Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 119586879
• NCBI GeneID: 7011
• UniProt Accession #: Q99973; A0AUV9; Q59EZ2
• Molecular Weight: 290,490 Da
• NCBI Official Full Name: telomerase-associated protein 1
• NCBI Official Synonym Full Names: telomerase-associated protein 1
• NCBI Official Symbol: TEP1
• NCBI Official Synonym Symbols: TP1; TLP1; p240; TROVE1; VAULT2
• NCBI Protein Information: telomerase protein component 1; OTTHUMP00000028244; telomerase protein 1; p80 telomerase homolog; TROVE domain family, member 1
• UniProt Protein Name: Telomerase protein component 1
• Protein Family: Telomerase protein component
• UniProt Gene Name: TEP1
• UniProt Synonym Gene Names: TLP1; TP1
• UniProt Entry Name: TEP1_HUMAN

NCBI Description

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. [provided by RefSeq]

Uniprot Description

TEP1: Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi- subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: chromosome, telomeric region; nuclear matrix; telomerase holoenzyme complex; cytoplasm; ribonucleoprotein complex

Molecular Function: telomerase activity; RNA binding; ATP binding

Biological Process: RNA-dependent DNA replication; telomere maintenance via recombination