Rabbit anti-Rat TEK Tyrosine Kinase, Endothelial (Tie2) Polyclonal Antibody | anti-Tie2 antibody

APC-Linked Polyclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2)

Gene Names

TEK; TIE2; VMCM; GLC3E; TIE-2; VMCM1; CD202B

Reactivity

Rat

Applications

Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA

Synonyms

TEK Tyrosine Kinase; Endothelial (Tie2); Polyclonal Antibody; APC-Linked Polyclonal Antibody to TEK Tyrosine Kinase; CD202b; CD202-B; TEK; VMCM1; Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 2; Venous Malformations Multiple Cutaneous And Mucosal; anti-Tie2 antibody

Ordering
Cat. Num. AAA2038313 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Host

Rabbit

Reactivity

Rat

Clonality

Polyclonal

Concentration

>=100ug/ml (varies by lot)

Applicable Applications for anti-Tie2 antibody

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

Immunogen

Tie2 (Cys44~Glu341)

Conjugation

APC

Cross Reactivity

Rat

Unconjugated Antibody

The unconjugated antibody version of this item is also available as catalog #MBS2027691

NCBI and Uniprot Product Information

NCBI GI #

112180440

NCBI GeneID

7010

Molecular Weight

109,141 Da

NCBI Official Full Name

TEK tyrosine kinase, endothelial

NCBI Official Synonym Full Names

TEK receptor tyrosine kinase

NCBI Official Symbol

TEK

NCBI Official Synonym Symbols

TIE2; VMCM; GLC3E; TIE-2; VMCM1; CD202B

NCBI Protein Information

angiopoietin-1 receptor

UniProt Protein Name

Angiopoietin-1 receptor

Protein Family

Tyrosine-protein kinase receptor

UniProt Gene Name

TEK

UniProt Synonym Gene Names

TIE2; VMCM; VMCM1; hTIE2

NCBI Description

This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

Uniprot Description

TIE2: a receptor tyrosine kinase of the Tie family. Receptor for angiopoietin 1. Expressed almost exclusively in endothelial cells. May constitute the earliest mammalian endothelial cell lineage marker. Appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Tie family

Chromosomal Location of Human Ortholog: 9p21.2

Cellular Component: actin filament; apical plasma membrane; basal plasma membrane; basolateral plasma membrane; cell surface; integral to plasma membrane; intercellular junction; lipid raft; microvillus; plasma membrane; stress fiber

Molecular Function: protein binding; protein kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor activity

Biological Process: angiogenesis; cell-cell signaling; endothelial cell proliferation; heart development; leukocyte migration; MAPKKK cascade; negative regulation of angiogenesis; negative regulation of apoptosis; negative regulation of inflammatory response; peptidyl-tyrosine phosphorylation; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; positive regulation of focal adhesion formation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade; protein amino acid autophosphorylation; protein oligomerization; regulation of establishment and/or maintenance of cell polarity; regulation of vascular permeability; signal transduction; sprouting angiogenesis; Tie receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Venous Malformations, Multiple Cutaneous And Mucosal

Research Articles on Tie2

1. High Ang 1 expression in hilar cholangiocarcinoma and infiltration of TIE2-expressing monocytes (TEMs) defines a subgroup of patients with beneficial tumor characteristics and prolonged survival. Low Ang 2 levels tended to inversely correlate with TEMs invasion.

Similar Products

Product Notes

The Tie2 tek (Catalog #AAA2038313) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APC-Linked Polyclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TEK Tyrosine Kinase, Endothelial (Tie2) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the Tie2 tek for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TEK Tyrosine Kinase, Endothelial (Tie2), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Loading...