Rabbit TEC Polyclonal Antibody | anti-TEC antibody

TEC (R220) Polyclonal Antibody

Cat. Num. AAA3000249

• Gene Names: TEC; PSCTK4
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TEC; Polyclonal Antibody; TEC (R220) Polyclonal Antibody; Tyrosine-protein kinase Tec; PSCTK4; anti-TEC antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TEC (R220) polyclonal antibody detects endogenous levels of TEC protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 631

• Applicable Applications for anti-TEC antibody: Western Blot (WB)
• Application Notes: WB: 1:1000-1:2000
• Immunogen: Synthetic peptide, corresponding to amino acids 190-250 of Human TEC.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of TEC (R220) polyclonal antibody at 1:500 dilutionLane1:Myla2059 whole cell lysate (40ug) Lane2:K562 whole cell lysate (40ug) Lane3:The Spleen tissue lysate of Rat (40ug) Lane4:The Spleen tissue lysate of Mouse (40ug))

Related Product Information for anti-TEC antibody

Tec kinase belongs to a structurally related subfamily of protein tyrosine kinases (PTKs) that includes Btk, Itk (also known as Emt or Tsk), Bmx, and Txk (or Rlk). With the exception of Txk, the members of this subfamily possess a long amino-terminal region consisting of a pleckstrin homology (PH) domain and a Tec homology (TH) domain. Because PH domains bind phosphoinositides with high affinity, the Tec family kinases have been proposed to act downstream of phosphatidylinositol 3-kinase (PI3-kinase) in signaling pathways. Binding of the PH domain with phosphoinositides is probably required for targeting of Tec family kinases to the cell membrane. Tec kinase is activated in response to many upstream signaling events including antigen receptor, RTK, GPCR, and integrin stimulation. Activated Tec kinase directly phosphorylates substrates such as PLC-gamma 2 and BRDG1 docking protein and mediates downstream signaling.

NCBI and Uniprot Product Information

• NCBI GI #: 130977759
• NCBI GeneID: 7006
• NCBI Accession #: NP_003206.2
• NCBI GenBank Nucleotide #: NP_003206.2
• UniProt Accession #: P42680
• Molecular Weight: ~ 58-75kDa
• NCBI Official Full Name: tyrosine-protein kinase Tec
• NCBI Official Synonym Full Names: tec protein tyrosine kinase
• NCBI Official Symbol: TEC
• NCBI Official Synonym Symbols: PSCTK4
• NCBI Protein Information: tyrosine-protein kinase Tec
• UniProt Protein Name: Tyrosine-protein kinase Tec
• Protein Family: Tectonic
• UniProt Gene Name: TEC
• UniProt Synonym Gene Names: PSCTK4
• UniProt Entry Name: TEC_HUMAN

NCBI Description

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]