Rabbit anti-Human TCEAL1 Polyclonal Antibody | anti-TCEAL1 antibody

TCEAL1, NT (TCEAL1, SIIR, Transcription elongation factor A protein-like 1, Nuclear phosphoprotein p21/SIIR, Transcription elongation factor S-II protein-like 1) (APC)

Cat. Num. AAA6354360

• Gene Names: TCEAL1; p21; SIIR; WEX9; pp21
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TCEAL1; Polyclonal Antibody; NT (TCEAL1; SIIR; Transcription elongation factor A protein-like 1; Nuclear phosphoprotein p21/SIIR; Transcription elongation factor S-II protein-like 1) (APC); Transcription elongation factor S-II protein-like 1; anti-TCEAL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-TCEAL1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TCEAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TCEAL1.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(TCEAL1 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TCEAL1 antibody detected the TCEAL1 protein (arrow).)

Related Product Information for anti-TCEAL1 antibody

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform.

Product Categories/Family for anti-TCEAL1 antibody

Antibodies; Transcription Factors

References

Chung, C.J., et al. Toxicol. Appl. Pharmacol. 232(2):203-209(2008). Olsen, J.V., et al. Cell 127(3):635-648(2006). Lee, Y.L., et al. J. Lab. Clin. Med. 147(5):228-233(2006). Santos, A.M., et al. Eur. J. Cancer 42(7):958-963(2006). Santos, A.M., et al. Biochem. Biophys. Res. Commun. 340(1):256-262(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 55749424
• NCBI GeneID: 9338
• NCBI Accession #: NP_001006641.1; NP_001006640.1
• NCBI GenBank Nucleotide #: NM_001006640.1
• UniProt Accession #: Q15170; Q9UJQ9
• Molecular Weight: 18,641 Da
• NCBI Official Full Name: transcription elongation factor A protein-like 1
• NCBI Official Synonym Full Names: transcription elongation factor A like 1
• NCBI Official Symbol: TCEAL1
• NCBI Official Synonym Symbols: p21; SIIR; WEX9; pp21
• NCBI Protein Information: transcription elongation factor A protein-like 1
• UniProt Protein Name: Transcription elongation factor A protein-like 1
• Protein Family: Transcription elongation factor A protein
• UniProt Gene Name: TCEAL1
• UniProt Synonym Gene Names: SIIR; TCEA-like protein 1
• UniProt Entry Name: TCAL1_HUMAN

NCBI Description

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

Uniprot Description

SIIR: May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly. Belongs to the TFS-II family. TFA subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription initiation complex

Chromosomal Location of Human Ortholog: Xq22.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: transcription factor activity

Biological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter