Rabbit anti-Human TBX2 Polyclonal Antibody | anti-TBX2 antibody

TBX2, ID (TBX2, T-box transcription factor TBX2) (PE)

Cat. Num. AAA6354182

• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TBX2; Polyclonal Antibody; ID (TBX2; T-box transcription factor TBX2) (PE); T-box transcription factor TBX2; anti-TBX2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-TBX2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TBX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 413-442 amino acids from the Central region of human TBX2.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(TBX2 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TBX2 antibody detected the TBX2 protein (arrow).)

Related Product Information for anti-TBX2 antibody

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.

Product Categories/Family for anti-TBX2 antibody

Antibodies; Transcription Factors

References

Vance, K.W., et al. Mol. Biol. Cell 21(15):2770-2779(2010). Radio, F.C., et al. Am. J. Med. Genet. A 152A (8), 2061-2066 (2010): Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010). Zhao, J., et al. BMC Med. Genet. 11, 96 (2010): Liu, W.K., et al. Onkologie 33(5):241-245(2010).

NCBI and Uniprot Product Information

• NCBI GI #: 197333868
• NCBI GeneID: 6909
• NCBI Accession #: NP_005985.3
• NCBI GenBank Nucleotide #: NM_005994.3
• UniProt Accession #: Q13207; Q16424; Q7Z647
• Molecular Weight: 75,066 Da
• NCBI Official Full Name: T-box transcription factor TBX2
• NCBI Official Synonym Full Names: T-box 2
• NCBI Official Symbol: TBX2
• NCBI Protein Information: T-box transcription factor TBX2; T-box protein 2
• UniProt Protein Name: T-box transcription factor TBX2
• Protein Family: T-box transcription factor
• UniProt Gene Name: TBX2
• UniProt Synonym Gene Names: T-box protein 2
• UniProt Entry Name: TBX2_HUMAN

NCBI Description

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TBX2: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: transcription factor complex; nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding

Biological Process: cardiac muscle development; transcription, DNA-dependent; positive regulation of cell proliferation; cell aging; embryonic digit morphogenesis; negative regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; palate development; negative regulation of transcription, DNA-dependent; muscle cell fate determination; positive regulation of cardiac muscle cell proliferation