Rabbit TBCE Polyclonal Antibody | anti-TBCE antibody

TBCE Rabbit Polyclonal

Cat. Num. AAA7604753

• Gene Names: TBCE; HRD; KCS; KCS1; pac2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: TBCE; Polyclonal Antibody; TBCE Rabbit Polyclonal; anti-TBCE antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 578

• Applicable Applications for anti-TBCE antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Tubulin folding cofactor E
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7604753 (TBCE antibody) at dilution of 1:50)

Western Blot (WB)

(human liver tissue were subjected to SDS PAGE followed by western blot with MBS7604753 (TBCE antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 568215736
• NCBI GeneID: 6905
• NCBI Accession #: NP_001274730.1
• NCBI GenBank Nucleotide #: NM_001287801.1
• Molecular Weight: 64,852 Da
• NCBI Official Full Name: tubulin-specific chaperone E isoform b
• NCBI Official Synonym Full Names: tubulin folding cofactor E
• NCBI Official Symbol: TBCE
• NCBI Official Synonym Symbols: HRD; KCS; KCS1; pac2
• NCBI Protein Information: tubulin-specific chaperone E
• UniProt Protein Name: Tubulin-specific chaperone E
• Protein Family: Tubulin-specific chaperone
• UniProt Gene Name: TBCE
• UniProt Entry Name: TBCE_HUMAN

NCBI Description

Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TBCE: Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation. Defects in TBCE are a cause of hypoparathyroidism- retardation-dysmorphism syndrome (HRD); also known as hypoparathyroidism with short stature, mental retardation, and seizures or Sanjad-Sakati syndrome. HRD is an autosomal recessive disorder reported almost exclusively in Middle Eastern populations. Defects in TBCE are the cause of Kenny-Caffey syndrome type 1 (KCS1). KCS1 is similar to HRD with the additional features of osteosclerosis and recurrent bacterial infections. Belongs to the TBCE family.

Protein type: Chaperone

Chromosomal Location of Human Ortholog: 1q42.3

Cellular Component: cytoplasm; microtubule

Molecular Function: chaperone binding

Biological Process: adult locomotory behavior; developmental growth; microtubule cytoskeleton organization and biogenesis; muscle atrophy; peripheral nervous system neuron axonogenesis; post-chaperonin tubulin folding pathway; post-embryonic development; protein folding

Disease: Hypoparathyroidism-retardation-dysmorphism Syndrome; Kenny-caffey Syndrome, Type 1