Western Blot (WB)
(TBC1D10B Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TBC1D10B antibody detected the TBC1D10B protein (arrow).)
Rabbit anti-Human TBC1D10B Polyclonal Antibody | anti-TBC1D10B antibody
TBC1D10B Antibody (C-term)
Gene Names
TBC1D10B; EPI64B; FP2461
Reactivity
Human
Applications
Western Blot, ELISA
Purity
This antibody is purified through a protein A column, followed by peptide affinity purification.
Synonyms
TBC1D10B; Polyclonal Antibody; TBC1D10B Antibody (C-term); TBC1 domain family member 10B; Rab27A-GAP-beta; anti-TBC1D10B antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This TBC1D10B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 781-808 amino acids from the C-terminal region of human TBC1D10B.
Purity/Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Sequence Positions
781-808
Sequence Length
233
Applicable Applications for anti-TBC1D10B antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Function
Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A.
Cellular Location
Cytoplasm. Note=In melanocytes, located at the periphery of cells
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(TBC1D10B Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TBC1D10B antibody detected the TBC1D10B protein (arrow).)
Western Blot (WB)
(TBC1D10B Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TBC1D10B antibody detected the TBC1D10B protein (arrow).)
Related Product Information for anti-TBC1D10B antibody
Small G proteins of the RAB family (Please inquire) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (Please inquire) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family (Ishibashi et al., 2009 [PubMed 19077034]).
Product Categories/Family for anti-TBC1D10B antibody
References
Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)
Choy, K.W., et al. Physiol. Genomics 25(1):9-15(2006)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Choy, K.W., et al. Physiol. Genomics 25(1):9-15(2006)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
87199
NCBI Official Full Name
TBC1 domain family member 10B
NCBI Official Synonym Full Names
TBC1 domain family, member 10B
NCBI Official Symbol
TBC1D10B
NCBI Official Synonym Symbols
EPI64B; FP2461
NCBI Protein Information
TBC1 domain family member 10B
UniProt Protein Name
TBC1 domain family member 10B
Protein Family
UniProt Gene Name
TBC1D10B
UniProt Entry Name
TB10B_HUMAN
NCBI Description
Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM 609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family (Ishibashi et al., 2009 [PubMed 19077034]).[supplied by OMIM, Nov 2010]
Uniprot Description
TBC1D10B: a putative GTPase activating protein for Rab family protein(s).
Protein type: GAPs, Rab; GAPs
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cytoplasm; plasma membrane
Molecular Function: protein binding
Biological Process: retrograde transport, endosome to Golgi
Research Articles on TBC1D10B
Similar Products
Product Notes
The TBC1D10B tbc1d10b (Catalog #AAA9212498) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 781-808. The TBC1D10B Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TBC1D10B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the TBC1D10B tbc1d10b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TBC1D10B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
