Western Blot (WB)
(Western blot analysis of TBC1D1 expression in (A) 293 and (B) Daudi cell lysate with TBC1D1 antibody at 2 μg/ml.)
Rabbit anti-Human TBC1D1 Polyclonal Antibody | anti-TBC1D1 antibody
TBC1D1 Antibody
Gene Names
TBC1D1; TBC; TBC1
Reactivity
Human
Applications
ELISA, Western Blot
Purity
TBC1D1 Antibody is affinity chromatography purified via peptide column.
Synonyms
TBC1D1; Polyclonal Antibody; TBC1D1 Antibody; TBC; TBC1; KIAA1108; TBC1 domain family member 1; TBC1 (tre-2/USP6; BUB2; cdc16) domain family; member 1; anti-TBC1D1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
TBC1D1 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
1168
Applicable Applications for anti-TBC1D1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
TBC1D1 antibody can be used for detection of TBC1D1 by Western blot at 1 - 4 mug/mL.
Conjugate
Unconjugated
Immunogen
TBC1D1 antibody was raised against a 22 amino acid synthetic peptide from near the carboxy terminus of human TBC1D1.
Buffer
TBC1D1 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
TBC1D1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of TBC1D1 expression in (A) 293 and (B) Daudi cell lysate with TBC1D1 antibody at 2 μg/ml.)
Western Blot (WB)
(Western blot analysis of TBC1D1 expression in (A) 293 and (B) Daudi cell lysate with TBC1D1 antibody at 2 μg/ml.)
Related Product Information for anti-TBC1D1 antibody
TBC1D1 Antibody: TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
131,378 Da
NCBI Official Full Name
TBC1 domain family member 1 isoform 1
NCBI Official Synonym Full Names
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
NCBI Official Symbol
TBC1D1
NCBI Official Synonym Symbols
TBC; TBC1
NCBI Protein Information
TBC1 domain family member 1
UniProt Protein Name
TBC1 domain family member 1
Protein Family
UniProt Gene Name
TBC1D1
UniProt Synonym Gene Names
KIAA1108
UniProt Entry Name
TBCD1_HUMAN
NCBI Description
TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM, Mar 2008]
Uniprot Description
TBC1D1: a putative GTPase activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues.
Protein type: GAPs; GAPs, Rab; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 4p14
Cellular Component: cytosol; nucleus
Molecular Function: protein binding
Biological Process: regulation of protein localization
Research Articles on TBC1D1
Similar Products
Product Notes
The TBC1D1 tbc1d1 (Catalog #AAA151090) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TBC1D1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TBC1D1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). TBC1D1 antibody can be used for detection of TBC1D1 by Western blot at 1 - 4 mug/mL. Researchers should empirically determine the suitability of the TBC1D1 tbc1d1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TBC1D1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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