Rabbit TAX1BP3 Polyclonal Antibody | anti-TAX1BP3 antibody

TAX1BP3 Polyclonal Antibody

Cat. Num. AAA3009693

• Gene Names: TAX1BP3; TIP1; TIP-1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TAX1BP3; Polyclonal Antibody; TAX1BP3 Polyclonal Antibody; TIP1; TIP-1; anti-TAX1BP3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TAX1BP3 polyclonal antibody detects endogenous levels of TAX1BP3 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 98

• Applicable Applications for anti-TAX1BP3 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant protein of human TAX1BP3
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using TAX1BP3 antibody.)

Related Product Information for anti-TAX1BP3 antibody

May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.

NCBI and Uniprot Product Information

• NCBI GI #: 325296954
• NCBI GeneID: 30851
• NCBI Accession #: NP_001191627.1
• NCBI GenBank Nucleotide #: NP_001191627.1
• UniProt Accession #: O14907
• Molecular Weight: 14kDa
• NCBI Official Full Name: tax1-binding protein 3 isoform 2
• NCBI Official Synonym Full Names: Tax1 binding protein 3
• NCBI Official Symbol: TAX1BP3
• NCBI Official Synonym Symbols: TIP1; TIP-1
• NCBI Protein Information: tax1-binding protein 3
• UniProt Protein Name: Tax1-binding protein 3
• Protein Family: Tax1-binding protein
• UniProt Gene Name: TAX1BP3
• UniProt Synonym Gene Names: TIP-1
• UniProt Entry Name: TX1B3_HUMAN

NCBI Description

This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]

Uniprot Description

TAX1BP3: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.

Protein type: Cell cycle regulation; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: cytoplasm; plasma membrane; nucleus; actin cytoskeleton

Molecular Function: protein C-terminus binding; protein binding; beta-catenin binding

Biological Process: negative regulation of cell proliferation; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; Rho protein signal transduction