Rabbit anti-Human TAX1BP1 Polyclonal Antibody | anti-TAX1BP1 antibody

TAX1BP1, ID (TAX1BP1, T6BP, Tax1-binding protein 1, TRAF6-binding protein) (FITC)

Cat. Num. AAA6353779

• Gene Names: TAX1BP1; T6BP; TXBP151; CALCOCO3
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TAX1BP1; Polyclonal Antibody; ID (TAX1BP1; T6BP; Tax1-binding protein 1; TRAF6-binding protein) (FITC); TRAF6-binding protein; anti-TAX1BP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-TAX1BP1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TAX1BP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-429 amino acids from the Central region of human TAX1BP1.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TAX1BP1 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TAX1BP1 antibody detected the TAX1BP1 protein (arrow).)

Related Product Information for anti-TAX1BP1 antibody

The HTLV-1 Tax protein transcriptionally activates the HTLV-1 promoter. Tax also binds to and stimulates the expression of cellular genes, including transcription factors and other proteins (Gachon et al., 1998 [PubMed 9733879]).

Product Categories/Family for anti-TAX1BP1 antibody

Antibodies; Binding Proteins

References

Parvatiyar, K., et al. J. Biol. Chem. 285(20):14999-15009(2010). Ruiz, M.T., et al. Braz J Otorhinolaryngol 76(2):193-198(2010). Shembade, N., et al. Science 327(5969):1135-1139(2010). Dieguez-Gonzalez, R., et al. Ann. Rheum. Dis. 68(4):579-583(2009). Shembade, N., et al. EMBO J. 28(5):513-522(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 332634733
• NCBI GeneID: 8887
• NCBI Accession #: NP_006015.4; NP_001073333.1
• NCBI GenBank Nucleotide #: NM_006024
• UniProt Accession #: Q86VP1; O60398; O95770; Q13311; Q9BQG5; Q9UI88; A4D196; B4DKU7; E7ENV2
• Molecular Weight: 68,277 Da
• NCBI Official Full Name: Homo sapiens Tax1 (human T-cell leukemia virus type I) binding protein 1 (TAX1BP1), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: Tax1 (human T-cell leukemia virus type I) binding protein 1
• NCBI Official Symbol: TAX1BP1
• NCBI Official Synonym Symbols: T6BP; TXBP151; CALCOCO3
• NCBI Protein Information: tax1-binding protein 1; TRAF6-binding protein
• UniProt Protein Name: Tax1-binding protein 1
• Protein Family: Tax1-binding protein
• UniProt Gene Name: TAX1BP1
• UniProt Synonym Gene Names: T6BP
• UniProt Entry Name: TAXB1_HUMAN

NCBI Description

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

Uniprot Description

TAX1BP1: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1. Expressed in all tissues tested. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 7p15

Cellular Component: cytosol

Molecular Function: protein binding; metal ion binding; kinase binding

Biological Process: inhibition of NF-kappaB transcription factor; apoptosis; innate immune response; negative regulation of interferon type I production; negative regulation of apoptosis