Rabbit anti-Rat Taurine Transporter Polyclonal Antibody | anti-SLC6A6 antibody
Taurine Transporter (Tau1, TauT)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well.
Western Blot: 1-10ug/ml (ECL)
Immunohistochemistry: 2-20ug/ml
Immunofluorescence: 2-20ug/ml
NCBI and Uniprot Product Information
NCBI Description
Taurine (2-aminoethanesulfonic acid) is a major intracellular amino acid in mammals. It is involved in a number of important physiologic processes, including bile acid conjugation in hepatocytes, modulation of calcium flux and neural excitability, osmoregulation, detoxification, and membrane stabilization. The cells of most organisms respond to hypertonicity by the intracellular accumulation of high concentrations of small organic solutes (osmolytes) that, in contrast to high concentrations of electrolytes, do not perturb the function of macromolecules. The renal medulla is normally the only tissue in mammals that undergoes wide shifts in tonicity. Its hypertonicity when the kidney is excreting a concentrated urine is fundamental to water conservation. The taurine content of the renal medulla of rats infused with 5% NaCl is higher than that in controls, suggesting that taurine behaves as an osmolyte in the renal medulla. Indeed, taurine functions as an osmolyte in Madin-Darby canine kidney (MDCK) cells. When MDCK cells cultured in isotonic medium are switched to hypertonic medium, their content of taurine doubles through the taking up of taurine from the medium. Taurine transport in these cells is dependent on sodium and chloride ions and is localized primarily in the basolateral plasma membrane (summary by Uchida et al., 1992 [PubMed 1518851]).[supplied by OMIM]
Uniprot Description
TAUT: Required for the uptake of taurine. Transports both taurine and beta-alanine which requires sodium ions. Chloride ions are necessary for optimal uptake. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
Protein type: Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3p25.1
Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane
Molecular Function: taurine binding; neurotransmitter:sodium symporter activity; taurine:sodium symporter activity
Biological Process: amino acid metabolic process; taurine transport; transport; amino acid transport; neurotransmitter transport; ion transport; transmembrane transport
Research Articles on SLC6A6
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Product Notes
The SLC6A6 slc6a6 (Catalog #AAA616155) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Taurine Transporter (Tau1, TauT) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Taurine Transporter can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry. Dilution: ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well. Western Blot: 1-10ug/ml (ECL) Immunohistochemistry: 2-20ug/ml Immunofluorescence: 2-20ug/ml. Researchers should empirically determine the suitability of the SLC6A6 slc6a6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Taurine Transporter, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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