Rabbit Tau Polyclonal Antibody | anti-Tau antibody

Tau Antibody

Cat. Num. AAA9403640

• Gene Names: Mapt; pTau; Mtapt; RNPTAU
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
• Synonyms: Tau; Polyclonal Antibody; Tau Antibody; MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau; anti-Tau antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total Tau protein.
• Purity/Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 752

• Applicable Applications for anti-Tau antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500~1:1000
• Immunogen Type: Peptide-KLH
• Immunogen Description: Peptide sequence around aa. 725-729(T-G-S-I-D) derived from Rat Tau
• Target Name: Tau
• Preparation and Storage: Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.

Western Blot (WB)

(Western blot analysis of extract from rat brain and mouse brain tissue using TAU Antibody)

Related Product Information for anti-Tau antibody

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Product Categories/Family for anti-Tau antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 13432197
• NCBI GeneID: 29477
• UniProt Accession #: P19332; Q63567; Q63677; Q9QW06
• Molecular Weight: 81,185 Da
• NCBI Official Full Name: Microtubule-associated protein tau
• NCBI Official Synonym Full Names: microtubule-associated protein tau
• NCBI Official Symbol: Mapt
• NCBI Official Synonym Symbols: pTau; Mtapt; RNPTAU
• NCBI Protein Information: microtubule-associated protein tau
• UniProt Protein Name: Microtubule-associated protein tau
• Protein Family: Tautomerase
• UniProt Gene Name: Mapt
• UniProt Synonym Gene Names: Mtapt; Tau; PHF-tau
• UniProt Entry Name: TAU_RAT

NCBI Description

a microtubule-associated protein; expression is found specifically in neurons [RGD, Feb 2006]

Uniprot Description

Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization.

Protein type: Cytoskeletal

Cellular Component: microtubule; neuron projection; cell; postsynaptic density; cytosol; microtubule cytoskeleton; growth cone; axon; tubulin complex; cytoplasm; plasma membrane; intracellular; axoneme; nucleus

Molecular Function: protein domain specific binding; protein binding; enzyme binding; protein phosphatase 2A binding; microtubule binding; protein complex binding; apolipoprotein binding; protein kinase binding; SH3 domain binding

Biological Process: apoptosis; axon extension; positive regulation of axon extension; positive regulation of microtubule polymerization; neuron migration; axon cargo transport; microtubule cytoskeleton organization and biogenesis; female pregnancy; adult walking behavior; microtubule-based process; mitochondrion transport along microtubule; response to organic substance; neuron differentiation; negative regulation of intracellular transport; axonogenesis; regulation of autophagy; brain development; induction of apoptosis by oxidative stress; response to nutrient