Rabbit TAT Polyclonal Antibody | anti-TAT antibody

TAT (E304) Polyclonal Antibody

Cat. Num. AAA3003872

• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TAT; Polyclonal Antibody; TAT (E304) Polyclonal Antibody; Tyrosine aminotransferase; L-tyrosine: 2-oxoglutarate aminotransferase; anti-TAT antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TAT (E304) polyclonal antibody detects endogenous levels of TAT protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 454

• Applicable Applications for anti-TAT antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 270-320 of Human TAT.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of TAT (E304) pAb in paraffin-embedded human breast carcinoma tissue.)

Related Product Information for anti-TAT antibody

TAT (tyrosine aminotransferase) is a 454 amino acid protein that localizes to mitochondria and belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Existing as a homodimer, TAT uses pyridoxal phosphate as a cofactor to catalyze the conversion of L-tyrosine into p-hydroxyphenylpyruvate, a reaction that is important in amino acid degradation. Defects in the gene encoding TAT are the cause of tyrosinemia type 2 (TYRO2), an inborn error of metabolism that is associated with elevated levels of tyrosine in blood and urine and is characterized by palmoplantar keratosis, painful corneal ulcers and mental retardation. The gene encoding TAT maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome.

NCBI and Uniprot Product Information

• NCBI GI #: 4507369
• NCBI GeneID: 6898
• NCBI Accession #: NP_000344.1
• NCBI GenBank Nucleotide #: NP_000344.1
• UniProt Accession #: P17735
• Molecular Weight: ~ 51kDa
• NCBI Official Full Name: tyrosine aminotransferase
• NCBI Official Synonym Full Names: tyrosine aminotransferase
• NCBI Official Symbol: TAT
• NCBI Protein Information: tyrosine aminotransferase
• UniProt Protein Name: Tyrosine aminotransferase
• Protein Family: Tat-binding
• UniProt Gene Name: TAT
• UniProt Synonym Gene Names: TAT

NCBI Description

This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible cognitive disability. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008]

Uniprot Description

TAT: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. Defects in TAT are the cause of tyrosinemia type 2 (TYRO2); also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - tyrosine; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; EC 2.6.1.5; Mitochondrial; Transferase

Chromosomal Location of Human Ortholog: 16q22.2

Cellular Component: cytosol

Molecular Function: tyrosine transaminase activity

Biological Process: 2-oxoglutarate metabolic process; glutamate metabolic process; L-phenylalanine catabolic process; tyrosine catabolic process

Disease: Tyrosinemia, Type Ii