Rabbit anti-Human TAS2R13 Polyclonal Antibody | anti-TAS2R13 antibody

TAS2R13, CT (TAS2R13, Taste receptor type 2 member 13, Taste receptor family B member 3) (PE)

Cat. Num. AAA6353687

• Gene Names: TAS2R13; TRB3; T2R13
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TAS2R13; Polyclonal Antibody; CT (TAS2R13; Taste receptor type 2 member 13; Taste receptor family B member 3) (PE); Taste receptor family B member 3; anti-TAS2R13 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-TAS2R13 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TAS2R13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-228 amino acids from the C-terminal region of human TAS2R13.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(TAS2R13 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TAS2R13 antibody detected the TAS2R13 protein (arrow).)

Related Product Information for anti-TAS2R13 antibody

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.

Product Categories/Family for anti-TAS2R13 antibody

Antibodies; Receptors

References

Lamesch, P., et al. Genomics 89(3):307-315(2007). Go, Y., et al. Genetics 170(1):313-326(2005). Fischer, A., et al. Mol. Biol. Evol. 22(3):432-436(2005). Zhang, Y., et al. Cell 112(3):293-301(2003). Montmayeur, J.P., et al. Curr. Opin. Neurobiol. 12(4):366-371(2002).

NCBI and Uniprot Product Information

• NCBI GI #: 12965178
• NCBI GeneID: 50838
• NCBI Accession #: NP_076409.1
• NCBI GenBank Nucleotide #: NM_023920.2
• UniProt Accession #: Q9NYV9; Q4G0I5; Q502V8; Q645X2
• Molecular Weight: 35,118 Da
• NCBI Official Full Name: taste receptor type 2 member 13
• NCBI Official Synonym Full Names: taste receptor, type 2, member 13
• NCBI Official Symbol: TAS2R13
• NCBI Official Synonym Symbols: TRB3; T2R13
• NCBI Protein Information: taste receptor type 2 member 13; taste receptor family B member 3; taste receptor, family B, member 3
• UniProt Protein Name: Taste receptor type 2 member 13
• Protein Family: Taste receptor
• UniProt Gene Name: TAS2R13
• UniProt Synonym Gene Names: T2R13; TRB3
• UniProt Entry Name: T2R13_HUMAN

NCBI Description

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

Uniprot Description

TAS2R13: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Belongs to the G-protein coupled receptor T2R family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, T2R family

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: plasma membrane; integral to membrane

Molecular Function: bitter taste receptor activity; taste receptor activity

Biological Process: positive regulation of cytokinesis; G-protein coupled receptor protein signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste