Rabbit TAO kinase 2 Polyclonal Antibody | anti-TAOK2 antibody
Rabbit anti-human TAO kinase 2 polyclonal Antibody
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
TAO2: a serine/threonine-protein kinase of the STE20 family. Activates the p38 MAPK signaling pathway through the specific activation of the upstream kinases MKK3 and MKK6. A potential multi-pass membrane protein. Activated in the DNA damage response and regulates the G2/M transition DNA damage checkpoint. Interacts with tubulins through the C-terminal domain. Involved in apoptotic processes such as membrane blebbing and apoptotic body formation. Prevents TAK1-mediated activation of IKK-alpha, and thus NF-kappa-B activation. May play a role in the osmotic stress-JNK1 pathway. An autism spectrum disorder susceptibility gene. Affects basal dendrite formation and axonal projections in cortical pyramidal neurons. Interacts with NRP1 (neuropilin 1), a receptor for the secreted guidance protein semaphorin 3A (Sema3A). Influences the formation of basal dendrites through the activation of JNK. Three isoforms of the human protein are produced by alternative splicing. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus. Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus.
Protein type: Membrane protein, multi-pass; Protein kinase, STE; Membrane protein, integral; Kinase, protein; Apoptosis; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; STE group; STE20 family; TAO subfamily
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cytoplasmic vesicle membrane; cytoskeleton; cytoplasm; dendrite; cytoplasmic membrane-bound vesicle; integral to membrane; nucleolus; nucleus; receptor complex
Molecular Function: protein serine/threonine kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; ATP binding
Biological Process: focal adhesion formation; cell migration; activation of MAPKK activity; apoptosis; stress-activated MAPK cascade; positive regulation of JNK cascade; protein amino acid phosphorylation; positive regulation of stress-activated MAPK cascade; regulation of cell shape; response to stress; regulation of cell growth; actin cytoskeleton organization and biogenesis; G2/M transition DNA damage checkpoint; protein targeting to membrane; response to DNA damage stimulus
Research Articles on TAOK2
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Product Notes
The TAOK2 taok2 (Catalog #AAA712633) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human TAO kinase 2 polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TAO kinase 2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the TAOK2 taok2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TAO kinase 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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