Western Blot (WB)
(Western Blot analysis of extracts from HT-29 and U-2 OS cells, untreated or synchronized in mitosis by thymidine block (2mM, 16h) followed by nocodozole treatment (100ng/ml, 24h), using MBS6003455.)
Rabbit anti-Human TACC3 Polyclonal Antibody | anti-TACC3 antibody
TACC3, phosphorylated (Ser558) (Transforming Acidic Coiled-coil Containing Protein 3, ERIC-1, ERIC1)
Purified by Protein A and peptide affinity chromatography.
Purified by Protein A and peptide affinity chromatography.
Dilution: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4 degree C with gentle shaking, overnight.
Western Blot (WB)
(Western Blot analysis of extracts from HT-29 and U-2 OS cells, untreated or synchronized in mitosis by thymidine block (2mM, 16h) followed by nocodozole treatment (100ng/ml, 24h), using MBS6003455.)
Western Blot (WB)
(Western Blot analysis of extracts from HT-29 and U-2 OS cells, untreated or synchronized in mitosis by thymidine block (2mM, 16h) followed by nocodozole treatment (100ng/ml, 24h), using MBS6003455.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
Uniprot Description
TACC3: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May be involved in the control of cell growth and differentiation. May contribute to cancer. Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminus region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2. Interacts with GCN5L2 and PCAF. Up-regulated in various cancer cell lines. Belongs to the TACC family.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: centrosome; cytoplasm
Molecular Function: protein domain specific binding; protein binding
Biological Process: regulation of microtubule-based process; cell proliferation; cytoplasmic sequestering of transcription factor; astral microtubule organization and biogenesis; neurogenesis; regulation of cell cycle; response to hypoxia; hemopoiesis; microtubule cytoskeleton organization and biogenesis; cerebral cortex development; interkinetic nuclear migration
Disease: Bladder Cancer
Research Articles on TACC3
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Product Notes
The TACC3 tacc3 (Catalog #AAA6003455) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TACC3, phosphorylated (Ser558) (Transforming Acidic Coiled-coil Containing Protein 3, ERIC-1, ERIC1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TACC3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4 degree C with gentle shaking, overnight. Researchers should empirically determine the suitability of the TACC3 tacc3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TACC3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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