Synuclein, beta CT Polyclonal Antibody | anti-SNCB antibody
Anti - Synuclein, beta CT (Phosphoneuroprotein 14, PNP14)
Gene Names
SNCB; SNCB
Reactivity
Bovine, Human
Applications
ELISA, Western Blot
Purity
Neat Serum
Synonyms
Synuclein; beta CT; Polyclonal Antibody; Anti - Synuclein; beta CT (Phosphoneuroprotein 14; PNP14); anti-SNCB antibody
Host
Host: Rabbit
Source: Human
Source: Human
Reactivity
Bovine, Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human, mouse and rat beta Synuclein. The peptide sequence corresponding to human beta-synuclein (134 aa) is identical in rat beta-synuclein (137 aa) and bovine PNP14 (134 aa). It has no appreciable homology with synuclein-alpha or other proteins.
Purity/Purification
Neat Serum
Form/Format
Serum
Undiluted, neat serum, preservative added
Undiluted, neat serum, preservative added
Sequence Length
134
Applicable Applications for anti-SNCB antibody
ELISA, Western Blot
Application Notes
Suitable for use in ELISA and Western Blot. Other applications not tested.
Dilution: ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well
Western Blot: 1:1000-1:5000
Optimal dilutions to be determined by the researcher.
Dilution: ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well
Western Blot: 1:1000-1:5000
Optimal dilutions to be determined by the researcher.
Immunogen
15 aa peptide located near the C-terminus of human synuclein-beta
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-SNCB antibody
Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. One of the most important and initial step involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43aa peptides (beta amyloid1-40, 1-42, and 1-43). Polymerization of b-amyloid (Ab) and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition. Ab deposits have also been found to contain 2 additional proteins termed a-synuclein and b-synuclein. The 140 aa a-synucleins is identical with non-Ab component (NACP) of AD. The 134aa b-synuclein is homologous to 14kD bovine phosphoneuroprotein 14. Mutations in a-synuclein gene causing a replacement of alanine with a threonine has the potential to cause the protein to misfold. Synucleins are primarily expressed in the brain. At least 3 forms, two large (140aa SYN-1 & 149 aa SYN-2) and a small form (SYN-3, 42 aa) are produced by alternative splicing.
Product Categories/Family for anti-SNCB antibody
References
• 1. Tobe T et al (1992) J Neurochem. 59, 1624-1629; Jakes, R et al (1994) FEBS Lett 345, 27-32
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
14,288 Da
NCBI Official Full Name
synuclein, beta
NCBI Official Synonym Full Names
synuclein, beta
NCBI Official Symbol
SNCB
NCBI Official Synonym Symbols
SNCB
NCBI Protein Information
beta-synuclein; OTTHUMP00000223369; OTTHUMP00000223370
UniProt Protein Name
Beta-synuclein
Protein Family
UniProt Gene Name
SNCB
UniProt Entry Name
SYUB_HUMAN
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Product Notes
The SNCB sncb (Catalog #AAA610389) is an Antibody produced from Host: Rabbit Source: Human and is intended for research purposes only. The product is available for immediate purchase. The Anti - Synuclein, beta CT (Phosphoneuroprotein 14, PNP14) reacts with Bovine, Human and may cross-react with other species as described in the data sheet. AAA Biotech's Synuclein, beta CT can be used in a range of immunoassay formats including, but not limited to, ELISA, Western Blot. Suitable for use in ELISA and Western Blot. Other applications not tested. Dilution: ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well Western Blot: 1:1000-1:5000 Optimal dilutions to be determined by the researcher. Researchers should empirically determine the suitability of the SNCB sncb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Synuclein, beta CT, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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