Immunofluorescence (IF)
(Immunofluorescence staining of methanol-fixed Hela cells using Synaptotagmin 1/2 (Phospho-Thr202/199) Antibody.)
Rabbit Synaptotagmin 1/2 Polyclonal Antibody | anti-SYT1 antibody
Synaptotagmin 1/2 (Phospho-Thr202/199) Antibody
Immunofluorescence (IF)
(Immunofluorescence staining of methanol-fixed Hela cells using Synaptotagmin 1/2 (Phospho-Thr202/199) Antibody.)
Immunofluorescence (IF)
(Immunofluorescence staining of methanol-fixed Hela cells using Synaptotagmin 1/2 (Phospho-Thr202/199) Antibody.)
NCBI and Uniprot Product Information
NCBI Description
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]
Uniprot Description
SYT1: an integral membrane protein of synaptic vesicles thought to serve as a Ca(2+) sensor in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. Binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Protein type: Membrane protein, integral; Vesicle; Calcium-binding
Chromosomal Location of Human Ortholog: 12cen-q21
Cellular Component: SNARE complex; presynaptic membrane; synaptic vesicle; neuron projection; synaptic vesicle membrane; integral to membrane; plasma membrane; excitatory synapse; cell junction
Molecular Function: protein C-terminus binding; identical protein binding; clathrin binding; calcium-dependent phospholipid binding; transporter activity; calcium ion binding; calcium-dependent protein binding; calmodulin binding; protein binding; SNARE binding; phosphatidylinositol-4,5-bisphosphate binding; low-density lipoprotein receptor binding; phosphatidylserine binding; syntaxin-1 binding; phosphatidylinositol binding
Biological Process: regulation of synaptic transmission, glutamatergic; neurotransmitter secretion; positive regulation of vesicle fusion; pathogenesis; positive regulation of synaptic transmission; regulation of exocytosis; synaptic transmission; positive regulation of calcium ion-dependent exocytosis; synaptic vesicle exocytosis; vesicle docking; glutamate secretion; detection of calcium ion; protein homooligomerization
Research Articles on SYT1
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Product Notes
The SYT1 syt1 (Catalog #AAA9409167) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Synaptotagmin 1/2 (Phospho-Thr202/199) Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Synaptotagmin 1/2 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF). Immunofluorescence: 1:100~1:200. Researchers should empirically determine the suitability of the SYT1 syt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Synaptotagmin 1/2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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