Rabbit Synapsin I Polyclonal Antibody | anti-SYN1 antibody

Synapsin I, phosphorylated (Ser9) (Synapsin 1, Synapsin-1, SYN1, SYN-1, Synapsin-I, SYNI, SYN-I, Brain Protein 4.1, SYN1a, SYN1b, SYN-1a, SYN-1b)

Cat. Num. AAA623910

• Gene Names: SYN1; SYNI; SYN1a; SYN1b
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Synapsin I; Polyclonal Antibody; phosphorylated (Ser9) (Synapsin 1; Synapsin-1; SYN1; SYN-1; Synapsin-I; SYNI; SYN-I; Brain Protein 4.1; SYN1a; SYN1b; SYN-1a; SYN-1b); Anti -Synapsin I; anti-SYN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Synapsin I when phosphorylated at serine 9. Species Cross-Reactivity: mouse, rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

• Applicable Applications for anti-SYN1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1:500-1:1,000
• Immunogen: Synthetic phosphopeptide corresponding to human Synapsin I around the phosphorylation site of serine 9 (R-L-SP-D-S).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-SYN1 antibody

Synapsin is a neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is thought to function in the regulation of neurotransmitter release. Synapsin exists as a homodimer and at the subcellular level is located at the cell junction and synapse. It interacts with CAPON and forms a ternary complex with NOS1. Synapsin is a substrate of at least four different protein kinases and it is likely that phosphorylation plays a role in its regulation in the nerve terminal. Defects in SYN1 cause X-linked recessive epilepsy associated with variable learning disabilities and behavior disorders.

Product Categories/Family for anti-SYN1 antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 553654
• NCBI GeneID: 6853
• UniProt Accession #: P17600; O75825; Q5H9A9; B1AJQ1
• Molecular Weight: 74,111 Da
• NCBI Official Full Name: synapsin I
• NCBI Official Synonym Full Names: synapsin I
• NCBI Official Symbol: SYN1
• NCBI Official Synonym Symbols: SYNI; SYN1a; SYN1b
• NCBI Protein Information: synapsin-1; brain protein 4.1; OTTHUMP00000023229; OTTHUMP00000023230
• UniProt Protein Name: Synapsin-1
• Protein Family: Synapsin
• UniProt Gene Name: SYN1
• UniProt Entry Name: SYN1_HUMAN

NCBI Description

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Uniprot Description

SYN1: neuronal phosphoprotein which associates with the cytoplasmic surface of synaptic vesicles and binds to the cytoskeleton. May function in the regulation of neurotransmitter release and of axonogenesis and synaptogenesis. Mutations may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Two differentially spiced isoforms have been reported.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: Golgi apparatus; synaptic vesicle; dendrite; cell junction; cytosol

Molecular Function: protein binding; transporter activity; actin binding; calcium-dependent protein binding; protein kinase binding; catalytic activity; ATP binding

Biological Process: synaptic transmission; metabolic process; neurotransmitter secretion; regulation of neurotransmitter secretion

Disease: Epilepsy, X-linked, With Variable Learning Disabilities And Behavior Disorders