Mouse anti-Human IL18BP Monoclonal Antibody | anti-IL18BP antibody

IL18BP Monoclonal Antibody

Cat. Num. AAA3014317

• Gene Names: IL18BP; FVH; IL18BPa
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: IL18BP; Monoclonal Antibody; IL18BP Monoclonal Antibody; IL18 binding protein; IL-18BP; IL18 BP; IL18 BPa; IL18BPa; Interleukin 18 binding protein; Interleukin-18-binding protein; MC51L 53L 54L homolog gene product; Tadekinig alfa; Tadekinig-alfa.; anti-IL18BP antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b
• Specificity: This antibody detects endogenous levels of IL18BP and does not cross-react with related proteins
• Purity/Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 194

• Applicable Applications for anti-IL18BP antibody: Western Blot (WB)
• Application Notes: WB: 1:400-1000
• Immunogen: Recombinant full length Human IL18BP.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot detection of IL18BP antibody in CHO-K1 cells transfected by IL18BP-PDGFR fusion protein and K562 cell lysates using IL18BP antibody (1:400-1:1000 diluted).)

Related Product Information for anti-IL18BP antibody

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses.This protein is constitutively expressed and secreted in mononuclear cells.Elevated level of this protein is detected in the intestinal tissues of patients with Crohn´s disease.Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 89111125
• NCBI GeneID: 10068
• NCBI Accession #: NP_001034748.1
• NCBI GenBank Nucleotide #: NP_001034748.1
• UniProt Accession #: O95998
• Molecular Weight: Predicted Band Size: 37KDa; Observed Band Size: 37/40KDa
• NCBI Official Full Name: interleukin-18-binding protein isoform a
• NCBI Official Synonym Full Names: interleukin 18 binding protein
• NCBI Official Symbol: IL18BP
• NCBI Official Synonym Symbols: FVH; IL18BPa
• NCBI Protein Information: interleukin-18-binding protein
• UniProt Protein Name: Interleukin-18-binding protein
• Protein Family: Interleukin-18-binding protein
• UniProt Gene Name: IL18BP
• UniProt Synonym Gene Names: IL-18BP
• UniProt Entry Name: I18BP_HUMAN

NCBI Description

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Uniprot Description

IL18BP: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extracellular space; extracellular region

Molecular Function: receptor antagonist activity; interleukin-18 binding

Biological Process: T-helper 1 type immune response; response to lipopolysaccharide