Western Blot (WB)
(Fig-1: Western blot analysis of SWAP70. Anti-SWAP70 antibody (11-4012) was used at 0.5 ug/ml on h Liver lysate.)
Rabbit SWAP70 Polyclonal Antibody | anti-SWAP70 antibody
Polyclonal Antibody to SWAP70
Gene Names
SWAP70; HSPC321; SWAP-70
Reactivity
HumanPredicted: Mouse
Applications
Western Blot
Purity
PurifiedProtein A Chromatography
Synonyms
SWAP70; Polyclonal Antibody; Polyclonal Antibody to SWAP70; KIAA0640; HSPC321; Switch-associated protein 70; Antibody to SWAP70; Anti-SWAP70 Antibody; SWAP70 Antibody; anti-SWAP70 antibody
Host
Rabbit
Reactivity
Human
Predicted: Mouse
Predicted: Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified
Protein A Chromatography
Protein A Chromatography
Form/Format
25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Sequence Length
585
Applicable Applications for anti-SWAP70 antibody
Western Blot (WB)
Application Notes
WB: 0.5-1 ug/ml
Immunogen Information
A partial length recombinant SWAP70 protein (amino acids 1-203) was used as the immunogen for this antibody.
Antigen
SWAP70
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Western Blot (WB)
(Fig-1: Western blot analysis of SWAP70. Anti-SWAP70 antibody (11-4012) was used at 0.5 ug/ml on h Liver lysate.)
Western Blot (WB)
(Fig-1: Western blot analysis of SWAP70. Anti-SWAP70 antibody (11-4012) was used at 0.5 ug/ml on h Liver lysate.)
Related Product Information for anti-SWAP70 antibody
SWAP-70 is a 70 kDa multiple functional signaling proteins involved in formation of membrane ruffling induced by signal cascade of tyrosine kinase growth factor receptors. It is involved in regulating migration and invasion of trophoblast cells during the processes of embryonic implantation and placentation in primates. Though originally isolated from activated B lymphocytes, recently it has been found that it is widely expressed in various cell types and tissues. It has a high binding afinity to PI(3, 4)P2. Its intracellular localization has been reported to depend on cell activation. Stimulation of the B cell receptor triggers a translocation of SWAP-70 from the cytosol to the plasma membrane in B cells. This translocation required a functional PH-domain. SWAP-70 functions as the only B cell-specific component of an isotype switch recombination complex called SWAP. The SWAP complex has specificity for the switch regions upstream of the constant region immunoglobulin genes and it facilitates the transfer of DNA between switch regions. These features suggested that mutations in the gene encoding SWAP-70 might result in humoral immunodeficiency.
Product Categories/Family for anti-SWAP70 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
68,998 Da
NCBI Official Full Name
Switch-associated protein 70
NCBI Official Synonym Full Names
SWAP switching B-cell complex subunit 70
NCBI Official Symbol
SWAP70
NCBI Official Synonym Symbols
HSPC321; SWAP-70
NCBI Protein Information
switch-associated protein 70
UniProt Protein Name
Switch-associated protein 70
Protein Family
UniProt Gene Name
SWAP70
UniProt Synonym Gene Names
KIAA0640; SWAP-70
Uniprot Description
SWAP-70: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
Protein type: GEF; GEF, Rac/Rho
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: cell-cell adherens junction; cytoplasm
Molecular Function: protein binding
Research Articles on SWAP70
Similar Products
Product Notes
The SWAP70 swap70 (Catalog #AAA668800) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to SWAP70 reacts with Human Predicted: Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SWAP70 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 0.5-1 ug/ml. Researchers should empirically determine the suitability of the SWAP70 swap70 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SWAP70, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
