Rabbit anti-Human SUSD2 Polyclonal Antibody | anti-SUSD2 antibody

SUSD2, CT (SUSD2, Sushi Domain (SCR Repeat) Containing Protein 2, BK65A6.2, FLJ227781) (AP)

Cat. Num. AAA6352687

• Gene Names: SUSD2; BK65A6.2
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SUSD2; Polyclonal Antibody; CT (SUSD2; Sushi Domain (SCR Repeat) Containing Protein 2; BK65A6.2; FLJ227781) (AP); Sushi domain-containing protein 2; anti-SUSD2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-SUSD2 antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: IHC: 1:10-50; ELISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: SUSD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 715-745 amino acids from the C-terminal region of human SUSD2.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SUSD2 Antibody (C-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the SUSD2 antibody detected the SUSD2 protein (arrow).)

Immunohistochemistry (IHC)

(SUSD2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SUSD2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Product Categories/Family for anti-SUSD2 antibody

Antibodies; Cancer Markers

References

Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007): Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005). Dunham, I., et al. Nature 402(6761):489-495(1999). PMol Cancer Res. 2013 Jan;11(1):74-85. doi: 10.1158/1541-7786.MCR-12-0501-T. Epub 2012 Nov 6. Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis. Watson AP, Evans RL, Egland KA. Source Cancer Biology Research Center, Sanford Research, Sanford School of Medicine of The University of South Dakota, 2301 East 60th Street North, Sioux Falls, SD 57104. kristi.egland.sanfordhealth.org MID: 23131994 [PubMed-in process].

NCBI and Uniprot Product Information

• NCBI GI #: 10092665
• NCBI GeneID: 56241
• NCBI Accession #: NP_062547.1
• NCBI GenBank Nucleotide #: NM_019601.3
• UniProt Accession #: Q9UGT4; Q9H5Y6
• Molecular Weight: 90,208 Da
• NCBI Official Full Name: sushi domain-containing protein 2
• NCBI Official Synonym Full Names: sushi domain containing 2
• NCBI Official Symbol: SUSD2
• NCBI Official Synonym Symbols: BK65A6.2
• NCBI Protein Information: sushi domain-containing protein 2; Sushi domain (SCR repeat) containing
• UniProt Protein Name: Sushi domain-containing protein 2
• Protein Family: Sushi domain-containing protein
• UniProt Gene Name: SUSD2
• UniProt Entry Name: SUSD2_HUMAN

Uniprot Description

SUSD2: May play a role in breast tumorigenesis. {ECO:0000269|PubMed:23131994}. Interacts with LGALS1; leads to an increased amount of LGALS1 on the cell surface. {ECO:0000269|PubMed:23131994}

Protein type: Membrane protein, integral; Tumor suppressor

Chromosomal Location of Human Ortholog: 22q11-q12

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein binding; scavenger receptor activity; polysaccharide binding

Biological Process: receptor-mediated endocytosis; immune response