Western Blot (WB)
(Anti-Survivin antibody, Western blottingAll lanes: Anti Survivin at 0.5ug/mlLane 1: Mouse Kidney Tissue Lysate at 50ugLane 2: Mouse Liver Tissue Lysate at 50ugLane 3: Mouse Testis Tissue Lysate at 50ugPredicted bind size: 16KDObserved bind size: 16KD)
anti-Mouse Survivin Polyclonal Antibody | anti-Birc5 antibody
Anti-Survivin Antibody
Western Blot (WB)
(Anti-Survivin antibody, Western blottingAll lanes: Anti Survivin at 0.5ug/mlLane 1: Mouse Kidney Tissue Lysate at 50ugLane 2: Mouse Liver Tissue Lysate at 50ugLane 3: Mouse Testis Tissue Lysate at 50ugPredicted bind size: 16KDObserved bind size: 16KD)
Western Blot (WB)
(Anti-Survivin antibody, Western blottingAll lanes: Anti Survivin at 0.5ug/mlLane 1: Mouse Kidney Tissue Lysate at 50ugLane 2: Mouse Liver Tissue Lysate at 50ugLane 3: Mouse Testis Tissue Lysate at 50ugPredicted bind size: 16KDObserved bind size: 16KD)
Background: Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that in humans encoded by the BIRC5 gene. Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin gene contains 4 exons. This gene is mapped to chromosome 17q25 by pulsed field gel electrophoresis and single- and 2-color FISH. The survivin protein functions as inhibitor caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]
Uniprot Description
Survivin: an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described.
Protein type: Apoptosis
Cellular Component: apical plasma membrane; centriole; chromosome; chromosome, pericentric region; cytoplasm; cytoplasmic microtubule; cytoskeleton; cytosol; interphase microtubule organizing center; kinetochore; microtubule; midbody; nuclear chromosome; nucleus; spindle microtubule
Molecular Function: caspase inhibitor activity; chaperone binding; cofactor binding; cysteine protease inhibitor activity; enzyme binding; identical protein binding; metal ion binding; microtubule binding; protease inhibitor activity; protein binding; protein heterodimerization activity; protein homodimerization activity; Ran GTPase binding; tubulin binding; ubiquitin-protein ligase activity; zinc ion binding
Biological Process: apoptosis; cell cycle; cell division; chromosome segregation; cytokinesis; embryonic development; establishment of chromosome localization; G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization and biogenesis; mitosis; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of neuron apoptosis; negative regulation of peptidase activity; negative regulation of transcription, DNA-dependent; positive regulation of cell cycle; positive regulation of exit from mitosis; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; protein complex localization; regulation of mitotic cell cycle; regulation of signal transduction; regulation of transcription, DNA-dependent; spindle checkpoint; transcription, DNA-dependent
Research Articles on Birc5
Similar Products
Product Notes
The Birc5 birc5 (Catalog #AAA178275) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-Survivin Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Survivin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the Birc5 birc5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Survivin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
