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Western Blot (WB) (The anti-SULT1A1 Pab is used in Western blot to detect SULT1A1 in mouse kidney tissue lysate.)

Rabbit SULT1A1 Polyclonal Antibody | anti-SULT1A1 antibody

SULT1A1 Antibody (Center)

Gene Names
SULT1A1; PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; HAST1/HAST2
Reactivity
Human, mouse (Predicted Reactivity: Monkey)
Applications
Western Blot, ELISA
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
SULT1A1; Polyclonal Antibody; SULT1A1 Antibody (Center); Sulfotransferase 1A1; ST1A1; Aryl sulfotransferase 1; HAST1/HAST2; Phenol sulfotransferase 1; Phenol-sulfating phenol sulfotransferase 1; P-PST 1; ST1A3; Thermostable phenol sulfotransferase; Ts-PST; STP; STP1; anti-SULT1A1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, mouse (Predicted Reactivity: Monkey)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This SULT1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-160 amino acids from the Central region of human SULT1A1.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (varies by lot)
Sequence Positions
128-160
Sequence Length
295
Applicable Applications for anti-SULT1A1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(The anti-SULT1A1 Pab is used in Western blot to detect SULT1A1 in mouse kidney tissue lysate.)

Western Blot (WB) (The anti-SULT1A1 Pab is used in Western blot to detect SULT1A1 in mouse kidney tissue lysate.)

Western Blot (WB)

(Western blot analysis of SULT1A1 (arrow) using rabbit polyclonal SULT1A1 Antibody (Y143). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SULT1A1 gene.)

Western Blot (WB) (Western blot analysis of SULT1A1 (arrow) using rabbit polyclonal SULT1A1 Antibody (Y143). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SULT1A1 gene.)
Related Product Information for anti-SULT1A1 antibody
Sulphation is a significant detoxification pathway for diverse xenobiotics, yet this modification also plays an important role in the metabolism and bioactivation of many dietary and environmental mutagens, including heterocyclic amines implicated in the pathogenesis of several cancers. A major human sulfotransferase, SULT1A1, metabolizes and/or bioactivates many endogenous compounds and is implicated in a range of cancers because of its ability to transform xenobiotics to cellular mutagens and carcinogens. Genetic polymorphisms in human sulfotransferase 1A1 SULT1A1 have a major impact on SULT1A1 enzyme activity and affect the risk for cancer development in humans. A G--->A transition at codon 213 (CGC/Arg to CAC/His) of the SULT1A1 gene has been identified (SULT1A1*2), and individuals homozygous for the His allele have a markedly lower activity and stability of this enzyme than those with the high activity SULT1A1*1 allozyme, which has been associated with protection against dietary toxins and reduced susceptibility to colorectal and breast cancers.There is an increasing incidence of SULT1A1*1 homozygosity and decreasing incidence of SULT1A1*2 homozygosity with increasing age, indicating a potential association of SULT1A1*1 allozyme(s) with protection against cell and/or tissue damage during aging. CLN3, the locus for Batten disease, maps to the same region 16p12.1-p11.2 as SULT12A1, making SULT1A1 a candidate gene for this disorder.
Product Categories/Family for anti-SULT1A1 antibody
References
Carcinogenesis 25 (5), 773-778 (2004)
J. Biol. Chem. 279 (18), 18799-18805 (2004)
Cancer Lett. 202 (1), 61-69 (2003)
J. Biol. Chem. 278 (9), 7655-7662 (2003)
Int. J. Cancer 103 (1), 101-104 (2003)
Chem. Biol. Interact. 129 (1-2), 141-170 (2000)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
34165
NCBI Official Full Name
sulfotransferase 1A1 isoform a
NCBI Official Synonym Full Names
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
NCBI Official Symbol
SULT1A1
NCBI Official Synonym Symbols
PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; HAST1/HAST2
NCBI Protein Information
sulfotransferase 1A1
UniProt Protein Name
Sulfotransferase 1A1
Protein Family
UniProt Gene Name
SULT1A1
UniProt Synonym Gene Names
STP; STP1; ST1A1; P-PST 1; Ts-PST
UniProt Entry Name
ST1A1_HUMAN

NCBI Description

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SULT1A1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. Belongs to the sulfotransferase 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Energy Metabolism - sulfur; EC 2.8.2.1; Transferase

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: cytosol

Molecular Function: sulfotransferase activity; steroid sulfotransferase activity; flavonol 3-sulfotransferase activity; aryl sulfotransferase activity

Biological Process: estrogen metabolic process; flavonoid metabolic process; xenobiotic metabolic process; sulfation; catecholamine metabolic process; amine metabolic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process

Research Articles on SULT1A1

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Product Notes

The SULT1A1 sult1a1 (Catalog #AAA9211683) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 128-160. The SULT1A1 Antibody (Center) reacts with Human, mouse (Predicted Reactivity: Monkey) and may cross-react with other species as described in the data sheet. AAA Biotech's SULT1A1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SULT1A1 sult1a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SULT1A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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