Western Blot (WB)
(Western Blot analysis of STX11 in Mouse lung tissue using STX11 Rabbit pAb at dilution 1/400)
Rabbit anti-Human, Mouse STX11 Polyclonal Antibody | anti-STX11 antibody
STX11 Rabbit pAb
IHC-P: 1:25-1:100
Western Blot (WB)
(Western Blot analysis of STX11 in Mouse lung tissue using STX11 Rabbit pAb at dilution 1/400)
Western Blot (WB)
(Western Blot analysis of STX11 in Mouse lung tissue using STX11 Rabbit pAb at dilution 1/400)
Immunohistochemistry (IHC)
(Immunohistochemistry of STX11 in paraffin-embedded Human breast cancer tissue using STX11 Rabbit pAb at dilution 1/30. Predicted cell location: Cytoplasm)
Immunohistochemistry (IHC)
(Immunohistochemistry of STX11 in paraffin-embedded Human breast cancer tissue using STX11 Rabbit pAb at dilution 1/30. Predicted cell location: Cytoplasm)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]
Uniprot Description
STX11: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. Defects in STX11 are the cause of familial hemophagocytic lymphohistiocytosis type 4 (FHL4); also known as HPLH4. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T-lymphocytes in lymph nodes, spleen, and other organs is also found. Belongs to the syntaxin family.
Chromosomal Location of Human Ortholog: 6q24.2
Cellular Component: SNARE complex; Golgi apparatus; synaptic vesicle; plasma membrane; integral to membrane; endomembrane system
Molecular Function: SNAP receptor activity; protein binding; SNARE binding
Biological Process: synaptic vesicle fusion to presynaptic membrane; intracellular protein transport; vesicle docking; natural killer cell degranulation; cytotoxic T cell degranulation; neutrophil degranulation
Disease: Hemophagocytic Lymphohistiocytosis, Familial, 4
Research Articles on STX11
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Product Notes
The STX11 stx11 (Catalog #AAA4759028) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The STX11 Rabbit pAb reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's STX11 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:500-1:2000 IHC-P: 1:25-1:100. Researchers should empirically determine the suitability of the STX11 stx11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "STX11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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