Rabbit anti-Human STX11 Polyclonal Antibody | anti-STX11 antibody

STX11, NT (STX11, Syntaxin-11) (APC)

Cat. Num. AAA6352270

• Gene Names: STX11; FHL4; HLH4; HPLH4
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: STX11; Polyclonal Antibody; NT (STX11; Syntaxin-11) (APC); Syntaxin-11; anti-STX11 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-STX11 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: STX11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human STX11.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(STX11 Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the STX11 antibody detected the STX11 protein (arrow).)

Related Product Information for anti-STX11 antibody

This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis.

Product Categories/Family for anti-STX11 antibody

Antibodies; Syntaxin; Synaptotagmin; Synaptophysin

References

Marsh, R.A., et al. Pediatr Blood Cancer 55(1):134-140(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Danielian, S., et al. J. Clin. Immunol. 30(2):330-337(2010). zur Stadt, U., et al. Am. J. Hum. Genet. 85(4):482-492(2009). Marcelin, G., et al. Mamm. Genome 20(3):131-139(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 33667038
• NCBI GeneID: 8676
• NCBI Accession #: NP_003755.2
• NCBI GenBank Nucleotide #: NM_003764.3
• UniProt Accession #: O75558; O75378; O95148; Q5TCL6; E1P598
• Molecular Weight: 33,196 Da
• NCBI Official Full Name: syntaxin-11
• NCBI Official Synonym Full Names: syntaxin 11
• NCBI Official Symbol: STX11
• NCBI Official Synonym Symbols: FHL4; HLH4; HPLH4
• NCBI Protein Information: syntaxin-11
• UniProt Protein Name: Syntaxin-11
• Protein Family: Syntaxin
• UniProt Gene Name: STX11
• UniProt Entry Name: STX11_HUMAN

NCBI Description

This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]

Uniprot Description

STX11: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. Defects in STX11 are the cause of familial hemophagocytic lymphohistiocytosis type 4 (FHL4); also known as HPLH4. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T-lymphocytes in lymph nodes, spleen, and other organs is also found. Belongs to the syntaxin family.

Chromosomal Location of Human Ortholog: 6q24.2

Cellular Component: SNARE complex; Golgi apparatus; synaptic vesicle; plasma membrane; integral to membrane; endomembrane system

Molecular Function: SNAP receptor activity; protein binding; SNARE binding

Biological Process: synaptic vesicle fusion to presynaptic membrane; intracellular protein transport; vesicle docking; natural killer cell degranulation; cytotoxic T cell degranulation; neutrophil degranulation

Disease: Hemophagocytic Lymphohistiocytosis, Familial, 4